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Cabozantinib for Pheochromocytoma and Paraganglioma
Study Summary
This trial studies how well cabozantinib s-malate works in treating patients with pheochromocytomas or paragangliomas that have spread. Cabozantinib s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking the growth of new blood vessels necessary for tumor growth.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2019 Phase 2 trial • 13 Patients • NCT02315430Trial Design
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- Your lab test results are not within the normal range.I do not have any major ongoing health issues like heart or stomach problems.I cannot swallow pills.I am willing and able to follow the study rules and work with the research team.I agree to use contraception during and 4 months after the study, and I (if female) have a negative pregnancy test.My cancer cannot be removed with surgery.I have cancer that can be measured or is mainly in the bones.I've had a recent scan of all cancer sites within the last 28 days.You are expected to live for at least 3 more months.My tumor is confirmed as pheochromocytoma or paraganglioma.I have been treated with cabozantinib before.I haven't had certain types of radiation or experimental treatments recently.I haven't had any cancer treatments except for skin or cervical cancer in the last 2 years.Your blood and body chemistry tests need to be within certain ranges.You have a serious medical or mental health condition that, in the opinion of the doctor, would not be suitable for this study.I haven't had chemotherapy or biologic treatment recently.I am able to get out of my bed or chair and move around.My cancer has worsened in the last year according to RECIST 1.1.I understand the study requirements and have signed the consent form.
- Group 1: Treatment (cabozantinib s-malate)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any still available spots to join this research?
"According to clinicaltrials.gov, the current recruitment status of this medical trial is active. The initial advertisement for participation was posted on February 17th 2015 with a subsequent update released on June 7th 2021."
Are there any previous investigations concerning Cabozantinib S-malate?
"Presently, there are 109 ongoing examinations of Cabozantinib S-malate with 11 trials in the last stage. Even though most studies for this substance occur within Cordoba and Calabria, over 6800 facilities worldwide have begun research on it."
What is the capacity of this medical experiment to accommodate participants?
"Affirmative. The clinicaltrials.gov database attests that this trial is actively looking for volunteers, having been posted on February 17th 2015 and last revised June 7th 2021. Currently, 22 participants are to be enrolled from a single site."
Has Cabozantinib S-malate been accepted by the FDA as a viable therapeutic option?
"Cabozantinib S-malate was assigned a safety rating of 2 based on the Phase 2 trial's data, implying some evidence exists for its security yet none that can be used to verify its efficacy."
Is this trial a pioneering endeavor or is it modeled after existing research?
"To date, Cabozantinib S-malate has been studied extensively in 109 active trials across 45 countries and 1315 cities. Initially funded by Exelixis in 2012, the Phase 2 clinical trial included 86 participants who were part of a much larger study that yielded 750 completed tests since its inception."
What symptoms does Cabozantinib S-malate typically address?
"Cabozantinib S-malate is a commonly used medication to treat those who have already received anti-vegf drugs. It has also been known to help patients struggling with advanced renal cell carcinoma (arcc), adrenal medulla, and high risk cases."
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