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Chemotherapy + Radiation for Brain Cancer
Study Summary
This trial studies how well chemo + radiation works in treating newly diagnosed brain tumors in young patients.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2013 Phase 3 trial • 637 Patients • NCT00884741Trial Design
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Who is running the clinical trial?
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- My tumor is not located in the basal ganglia or thalamus.I have only had surgery or corticosteroids for my cancer.I am not pregnant.I am a woman able to have children and have a negative pregnancy test.My cancer fits into one of two specific types.I do not have a mature teratoma or a fully removed immature teratoma with normal tumor markers.I have been newly diagnosed with a specific type of brain tumor.I have completed the required imaging and lab tests.My hemoglobin level is at least 8.0 g/dL.My kidney function is normal or near normal.My bilirubin levels are within normal range for my age.
- Group 1: Treatment (combination chemotherapy, radiation therapy)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is it possible for me to partake in this experiment?
"In order to qualify for this medical trial, applicants must have germinoma and should be between 3-21 years of age. Currently, around 262 participants are needed."
Does the age requirement for this medical experiment restrict younger individuals?
"To qualify for this trial, applicants must be aged between 3 and 21 years old. According to the available data, there are 390 trials that cater to individuals in the younger age bracket while 1,316 studies focus on seniors."
How many medical facilities are actively engaged in this research endeavor?
"A total of 100 available slots are open in this research trial, including at Cedars Sinai Medical Center (Los Angeles), Mattel Children's Hospital UCLA (Oakland) and the Children's Hospital and Research Center at Oakland (Sacramento)."
Could you provide insight into the potential risks associated with Intensity-Modulated Radiation Therapy?
"Intensity-Modulated Radiation Therapy is classified as a low risk intervention, which has been assigned a score of 2. This designation takes into account the Phase 2 clinical trial data indicating safety but not efficacy."
Have extant studies explored the efficacy of Intensity-Modulated Radiation Therapy?
"Intensity-Modulated Radiation Therapy was first developed in 1997 at the City of Hope Comprehensive Cancer Center. To date, there are 2102 completed studies and 1537 active trials with many being conducted within Los Angeles, California."
What primary goals are being pursued with this clinical investigation?
"This 5-year clinical trial is aiming to measure the progression free survival (PFS) rate of those with Central Nervous System Germinoma who were treated with a reduced dose radiation therapy. Secondary objectives include assessing overall survival and PFS in certain demographics, such as patients with Cerebrospinal Fluid hCGbeta levels between 50 mIU/mL and 100 mIU/mL. These results will be evaluated through MRI scans, tumor markers assessments, and Kaplan Meier estimates over three years."
Are new members currently being enrolled for this research trial?
"Unfortunately, no new participants are being sought for this trial as it was last updated on December 9th 2021. However, if you look around other studies there are currently 64 clinical trials recruiting patients with germinoma and 1,537 seeking enrolment into Intensity-Modulated Radiation Therapy."
What maladies commonly respond to Intensity-Modulated Radiation Therapy?
"Intensity-Modulated Radiation Therapy may be utilized to effectively treat Merkel cell carcinoma, Leukemia and initial treatment."
What is the current enrollment capacity for this clinical trial?
"This clinical trial has concluded its recruitment process. The posting first went live on May 29th 2012 and was last updated December 9th 2021, so it is no longer open for participants. If you are still looking to join a medical study related to germinoma, there are currently 64 trials actively inviting enrolment; if Intensity-Modulated Radiation Therapy appeals more, 1537 studies are recruiting right now."
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