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Progesterone for Cannabis Use

Phase 2
Waitlist Available
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up immediately post stress/cue task.
Awards & highlights

Study Summary

This trial will study if progesterone can help marijuana users stress less and use less marijuana.

Eligible Conditions
  • Cannabis Use

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~immediately post stress/cue task.
This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately post stress/cue task. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cannabis Craving

Side effects data

From 2018 Phase 4 trial • 64 Patients • NCT02255175
18%
Breast Tenderness
15%
Cramps
15%
Itchiness at patch site
12%
Headaches
9%
Nausea
6%
Acne
6%
Lower Back Pain
6%
Hot Flashes
6%
Menstrual Bleeding
6%
Bloating
3%
Dizziness
100%
80%
60%
40%
20%
0%
Study treatment Arm
Perimenopausal Women, Depressed
Perimenopausal Women, Non-depressed

Trial Design

4Treatment groups
Experimental Treatment
Placebo Group
Group I: Progesterone MalesExperimental Treatment1 Intervention
35 men will take 400 mg of progesterone a day for 7 days and will complete a stress and marijuana cue reactivity task following the final dose.
Group II: Progesterone FemaleExperimental Treatment1 Intervention
35 women will take 200 mg of progesterone twice a day for 7 days and will complete a stress and marijuana cue reactivity task following the final dose.
Group III: Placebo FemalesPlacebo Group1 Intervention
35 women will take placebo twice a day for 7 days and will complete a stress and marijuana cue reactivity task following the final dose.
Group IV: Placebo MalesPlacebo Group1 Intervention
35 men will take placebo twice a day for 7 days and will complete a stress and marijuana cue reactivity task following the final dose.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Progesterone
2013
Completed Phase 4
~4510

Find a Location

Who is running the clinical trial?

National Institutes of Health (NIH)NIH
2,714 Previous Clinical Trials
7,510,186 Total Patients Enrolled
1 Trials studying Cannabis Use
48 Patients Enrolled for Cannabis Use
National Institute on Drug Abuse (NIDA)NIH
2,485 Previous Clinical Trials
2,622,188 Total Patients Enrolled
28 Trials studying Cannabis Use
6,240 Patients Enrolled for Cannabis Use
Medical University of South CarolinaLead Sponsor
937 Previous Clinical Trials
7,396,702 Total Patients Enrolled
3 Trials studying Cannabis Use
169 Patients Enrolled for Cannabis Use

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are some popular applications for Progesterone?

"Progesterone is often used to stop uterine bleeding and can also help with conditions like hormonal imbalance, prophylaxis of recurrent spontaneous preterm birth, and endometrial hyperplasia caused by conjugated estrogen."

Answered by AI

What is theTrack record of Progesterone in medical studies?

"There are currently 45 active clinical trials researching Progesterone. 8 of these trials have progressed to Phase 3 testing. Many of the participating research centres for these studies are based in Barcelona, Catalunya; though there are a total of 273 locations worldwide where these tests are taking place."

Answered by AI

How many individuals are being administered this medication in this test?

"Yes, this information is accurate. The study in question was posted on January 18th, 2019 and was last edited on March 16th, 2020. They are looking for a total of 140 patients from 1 site."

Answered by AI

Does Progesterone have the official backing of the FDA?

"Progesterone's safety is not as well established as other drugs, so it received a score of 2."

Answered by AI

Is this research project currently seeking middle-aged participants?

"This particular trial is onlyfor patients aged 18-45, though there are 26 clinical trials for those under 18 and 64 for senior citizens."

Answered by AI

Are patients currently being enrolled in this trial?

"According to the latest information available, this clinical trial is looking for patients. The listing was first posted on 1/18/2019 and updated as recently as 3/16/2022."

Answered by AI

Could I please inquire about the requirements to join this particular clinical trial?

"This clinical trial is looking for 140 patients that have a history of hashish abuse and meet the following criteria: 2. Meet DSM-5 criteria for moderate or severe cannabis use disorder (within the past three months) and report using cannabis at least five times weekly over the past month. While individuals may also meet criteria for mild use disorders of other substances, they must identify cannabis as their primary substance of abuse and must not meet criteria for any other moderate or severe substance use disorder (except tobacco) within the last 60 days., 3. Age 18-45. 4. For women, regular menses (every 25-35 days"

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Impact of Progesterone on Stress Reactivity and Cannabis Use
Aimee McRae-Clark 2019. "Impact of Progesterone on Stress Reactivity and Cannabis Use". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03729869.
~24 spots leftby May 2025
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