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Stem Cell Transplant for Blood Cancers
Study Summary
This trial is testing a new way to stop the donor's immune system from attacking the patient's body.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am currently pregnant or breastfeeding.I have had a stem cell transplant from a donor.My infection is not getting better with antibiotics.My heart pumps well, with an ejection fraction of 50% or higher.I am mostly able to care for myself.My lung function test shows at least half the expected value for someone my age and size.I have a blood cancer suitable for a stem cell transplant.I haven't had any cancer besides low-grade ones treated to cure in the last 5 years.I have a donor who is a perfect match for my bone marrow transplant.My age or organ function does not meet the study requirements.I am between the ages of 0 and 65.My kidneys are functioning well.I have an active brain tumor.
- Group 1: Radiation, Thiotepa & Cyclophosphamide
- Group 2: Busulfan, Fludarabine & Melphalan
- Group 3: Clofarabine, Thiotepa & Melphalan
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Could you please describe the side effects of Melphalan?
"Melphalan's safety protocols merit a score of 2 because, while there is some evidence backing its safety, none exists yet to support efficacy."
What is Melphalan most commonly used to treat?
"Melphalan is a medication most often used to treat lung cancers, but it can also be effective in treating b-cell lymphomas, polyangium, and multiple sclerosis."
Is Melphalan a common medication used in clinical trials?
"There are 1284 ongoing clinical trials related to Melphalan, with 238 of them being in Phase 3. Most investigations for Melphalan are based in Philadelphia, Pennsylvania; though, there 38467 locations worldwide where studies for Melphalan are conducted."
Is there still room for more people in this clinical trial?
"This particular study is no longer recruiting patients, as the last edit was on 8/18/2022. However, there are 3137 clinical trials currently underway for leukemia, lymphocytic, acute, l1 and 1284 studies involving Melphalan that are still looking for participants."
How many individuals are under observation in this clinical trial?
"This study has already completed recruitment for participants. The study was first posted on July 25th, 2018 and updated as recently as August 18th, 2022. Currently, there are 3137 trials actively searching for leukemia patients and 1284 Melphalan trials with open enrollment."
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