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SGLT2 Inhibitor

Dapagliflozin for Heart Failure

Phase 2
Waitlist Available
Led By Barry A Borlaug
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 24 weeks
Awards & highlights

Study Summary

This trial will test whether Dapa can improve heart function in people with HFpEF.

Eligible Conditions
  • Heart Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pulmonary Capillary Wedge Pressure (PCWP) at Maximal Exercise
Pulmonary Capillary Wedge Pressure (PCWP) at Rest
Secondary outcome measures
Change in Body Weight
Change in Mean Pulmonary Arterial Pressure (PA) at Maximal Exercise
Change in Mean Pulmonary Arterial Pressure (PA) at Rest
+4 more

Side effects data

From 2018 Phase 4 trial • 30 Patients • NCT03006471
20%
Cervicovaginal infection
13%
Urinary tract infections
100%
80%
60%
40%
20%
0%
Study treatment Arm
Dapagliflozin
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Dapagliflozin GroupExperimental Treatment1 Intervention
Subjects with HFpEF will take the study drug dapagliflozin daily
Group II: Placebo GroupPlacebo Group1 Intervention
Subjects with HFpEF will take a placebo daily
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dapagliflozin
2014
Completed Phase 4
~64440

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,252 Previous Clinical Trials
3,785,359 Total Patients Enrolled
72 Trials studying Heart Failure
1,021,692 Patients Enrolled for Heart Failure
Barry A BorlaugPrincipal InvestigatorMayo Clinic
1 Previous Clinical Trials
23 Total Patients Enrolled
1 Trials studying Heart Failure
23 Patients Enrolled for Heart Failure
~9 spots leftby Jun 2025
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