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2-HOBA for Atrial Fibrillation Recurrence
Study Summary
This trial is testing whether or not 2-HOBA can help reduce early recurrence of AF by binding to and inactivating IsoLG.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- I have not taken Amiodarone in the last 3 months.I am scheduled for a surgery that involves removing or destroying tissue.I have severe heart failure.I have a condition like rheumatoid arthritis or psoriasis.Your heart's pumping function is less than 35%.I am having my first AF ablation using either radiofrequency or cryo.I am 22 years old or older.I need another AF ablation because my atrial fibrillation persists and the doctor plans to target areas outside the pulmonary veins.I am currently taking oral steroids or colchicine.Doctors think you may live for less than a year.Your kidneys are not working well enough (creatinine clearance less than 30 ml/min).I have not had heart or chest surgery in the last 6 months.I have had or am planning to have a heart transplant.I am currently taking MAO inhibitors.I have active heart-related chest pain.I have been diagnosed with Hypertrophic Cardiomyopathy.You are allergic to aspirin.
- Group 1: Placebo
- Group 2: 2-HOBA
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any patients needed to participate in this ongoing research?
"Unfortunately, this particular trial is not recruiting at the moment according to the latest update on clinicaltrials.gov (June 1st, 2022). Although this specific study is no longer looking for volunteers, there are still over 1500 other trials that need participants."
How many individuals are being monitored as part of this research?
"Though this trial was posted on May 15th, 2020 and last updated June 1st, 2022, it is not currently recruiting patients. If you are interested in other studies, there are presently 1561 trials actively searching for participants with atrial fibrillation and 2 separate studies for 2-HOBA that need participants."
What is the existing literature on 2-HOBA's efficacy?
"Currently, there are two ongoing studies involving 2-HOBA. However, neither of the active research projects are in Phase 3. Most of the clinical trials related to 2-HOBA take place in Nashville, Tennessee; although, there are also two other locations running similar experiments."
Has 2-HOBA received any formalized acknowledgement from the FDA?
"Given that this is a phase 2 trial, and thus there is only limited data supporting its safety but none for efficacy, our team has given 2-HOBA a score of 2."
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