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Ultrasound guided Liposomal Bupivacaine Erector Spinae Block for Postoperative Pain

Phase 3
Waitlist Available
Led By Yar Yeap, MD
Research Sponsored by Indiana University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up nausea scores will be documented at 1 hour post op, 24,48,and 72 hours after the block. the scores will then be averaged
Awards & highlights

Study Summary

This trial is comparing the effects of 2 different types of pain relief after surgery; one with a block, one with a drug infusion. Outcomes include pain, opioid use, side effects, & patient satisfaction.

Eligible Conditions
  • Postoperative Pain
  • Acute Pain
  • Thoracic

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~sedation scores will be documented at 1 hour post op, 24,48,and 72 hours after the block. the scores will then be averaged.]
This trial's timeline: 3 weeks for screening, Varies for treatment, and sedation scores will be documented at 1 hour post op, 24,48,and 72 hours after the block. the scores will then be averaged.] for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The Primary endpoint of this study will be VAS pain score at 24 hours
The Primary endpoint of this study will be VAS pain score at.48 hours
Secondary outcome measures
Average Nausea scores over 72 hours
Average Sedation scores over 72 hours
Secondary endpoint includes total opioid consumption at 72 hours
+2 more

Trial Design

3Treatment groups
Active Control
Group I: Ultrasound guided Liposomal Bupivacaine Erector Spinae BlockActive Control2 Interventions
All the erector spinae plane blocks will be placed preoperatively using Liposomal Buvicaine. All procedures will be placed under the supervision of the attending anesthesiologist on the acute pain service or the attending anesthesiologist in the operating room.
Group II: Ultrasound guided Standard Bupivacaine Erector Spinae BlockActive Control1 Intervention
All the erector spinae plane blocks will be placed preoperatively using Liposomal Buvicaine. All procedures will be placed under the supervision of the attending anesthesiologist on the acute pain service or the attending anesthesiologist in the operating room.
Group III: Surgeon InfiltrationActive Control2 Interventions
At the end of the surgery, the surgeon will infiltrate liposomal bupivacaine under thoracoscopic guidance along the intercostal nerves from T4-T8.

Find a Location

Who is running the clinical trial?

Indiana UniversityLead Sponsor
989 Previous Clinical Trials
1,093,573 Total Patients Enrolled
5 Trials studying Postoperative Pain
1,902 Patients Enrolled for Postoperative Pain
Yar Yeap, MDPrincipal Investigator - Indiana University
Indiana University
6 Previous Clinical Trials
565 Total Patients Enrolled
1 Trials studying Postoperative Pain
70 Patients Enrolled for Postoperative Pain

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Indian Journal of AnaesthesiaJournal
Erector Spinae Plane Block an Effective Block for Post-operative Analgesia in Modified Radical Mastectomy
Singh, Swati, and NeerajKumar Chowdhary. 2018. “Erector Spinae Plane Block an Effective Block for Post-operative Analgesia in Modified Radical Mastectomy”. Indian Journal of Anaesthesia. Medknow. doi:10.4103/ija.ija_726_17.
Scandinavian Journal of PainJournal
Erector Spinae Plane (ESP) Block in the Management of Post Thoracotomy Pain Syndrome: A Case Series
Forero, Mauricio, Manikandan Rajarathinam, Sanjib Adhikary, and Ki Jinn Chin. 2017. “Erector Spinae Plane (ESP) Block in the Management of Post Thoracotomy Pain Syndrome: A Case Series”. Scandinavian Journal of Pain. Walter de Gruyter GmbH. doi:10.1016/j.sjpain.2017.08.013.
Regional Anesthesia and Pain MedicineJournal
The Erector Spinae Plane Block
Forero, Mauricio, Sanjib D. Adhikary, Hector Lopez, Calvin Tsui, and Ki Jinn Chin. 2016. “The Erector Spinae Plane Block”. Regional Anesthesia and Pain Medicine. BMJ. doi:10.1097/aap.0000000000000451.
Journal of Clinical AnesthesiaJournal
Evaluation of Ultrasound-guided Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled Clinical Trial
Tulgar, Serkan, Mahmut Sertan Kapakli, Ozgur Senturk, Onur Selvi, Talat Ercan Serifsoy, and Zeliha Ozer. 2018. “Evaluation of Ultrasound-guided Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled Clinical Trial”. Journal of Clinical Anesthesia. Elsevier BV. doi:10.1016/j.jclinane.2018.06.019.
~20 spots leftby May 2025
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