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Injectable Buprenorphine for Methamphetamine Use Disorder (CTN-0110 Trial)
CTN-0110 Trial Summary
This trial tests if a medication can help with Meth use disorder, with mild opioid use.
CTN-0110 Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowCTN-0110 Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.CTN-0110 Trial Design
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Logistics
Other reimbursement is provided
Other forms of reimbursement are provided for this trial.
Who is running the clinical trial?
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- I have passed a drug test for opioids during screening and on the day I expect to join the trial.I am scheduled for surgery or treatment that will need opioid painkillers.You have recently used opioids for at least two days in the past month or you have met 2-3 criteria for mild opioid use disorder (OUD) according to the DSM-5.You have participated in a drug or behavior addiction study within 6 months before agreeing to this study (except for smoking cessation).My doctor says my belly area isn't good for needle shots.I have taken buprenorphine or methadone in the last 30 days.I am not on any medication that could badly interact with the study drugs.I meet the specific requirements to participate in the study.People who cannot participate in the study:I can understand and speak English or Spanish.I agree to use birth control and undergo pregnancy tests if I can get pregnant.I am between 18 and 65 years old.You have participated in another study involving an experimental drug within 30 days before agreeing to participate in this study.I am currently pregnant, breastfeeding, or planning to become pregnant.You meet the criteria for moderate or severe MUD, which is determined by specific guidelines called DSM-5.I want to reduce or stop using methamphetamine.You have thoughts of harming yourself or others that require immediate help.You have other health or mental conditions that could make it hard or unsafe for you to participate, according to the medical clinician's judgment.
- Group 1: Injectable Buprenorphine (BUP-inj)
- Group 2: Injectable Placebo (PBO-inj)
- Screening: It may take up to 7 Weeks to process to see if you qualify in this trial.
- Treatment: You will receive the treatment for 12 Weeks
- Follow Ups: You may be asked to continue sharing information regarding the trial for 1 Months after you stop receiving the treatment.
Frequently Asked Questions
Does the current protocol permit seniors aged 75 and above to participate?
"This clinical trial is seeking participants whose age falls within the parameters of 18 years or older, and 65 years old or younger."
Has the Federal Drug Administration sanctioned Injectable Buprenorphine (BUP-inj) for medical use?
"The safety of BUP-inj is rated a 2 on our internal scale, as the clinical trial currently being conducted is only in its second phase. This indicates that while some data has been collected regarding it's safety, none exists yet to support efficacy."
Are enrollees being accepted to participate in this clinical investigation at present?
"Affirmative. Clinicaltrials.gov reports that the trial, which was first uploaded on March 1st 2023 and last modified on March 3rd of the same year, is actively recruiting patients. 246 volunteers need to be sourced from a single location for this research project."
To what extent is the cohort of this medical study being assessed?
"Affirmative. Clinicaltrials.gov hosts information that confirms the commencement of this clinical trial on March 1st, 2023 and its subsequent updates to recruit 246 participants from one medical centre."
How can I take part in this research project?
"This clinical trial is recruiting 246 individuals aged 18 to 65 with methamphetamine addiction. To be eligible, they must meet the following criteria: Be fluent in English or Spanish; Display signs of moderate-severe MUD (4+ DSM-5 Criteria); Report MA use on at least 18 days within the last 30 days before written consent; Provide 2 out of 3 positive urine samples for MA over 10 day period; Have mild OUD/evidence of opioid misuse via self report and UDS tests OR have a COWS score ≤8 at screening and randomization visits; Females must agree to contraceptive measures & periodic pregnancy testing unless unable to bear children"
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
What questions have other patients asked about this trial?
Why did patients apply to this trial?
How responsive is this trial?
Typically responds via
Most responsive sites:
- UCLA Vine Street Clinic: < 24 hours
Average response time
- < 2 Days
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