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AB1 for Sickle Cell Disease ((SCD) Trial)
(SCD) Trial Summary
This trial is testing a new drug by giving increasing doses to groups of patients to see what effects it has. The drug is taken orally once a day for 8 weeks.
(SCD) Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria below(SCD) Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.(SCD) Trial Design
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Who is running the clinical trial?
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- I haven't taken any experimental drugs in the last 28 days.I do not have any planned surgeries or major procedures during the study.I haven't had any severe sickle cell complications in the last 28 days.I have had severe sepsis or septic shock in the last 3 months.I am between 18 and 45 years old.I have been diagnosed with SS or Sβ0-thalassemia sickle cell disease.My heart condition severely limits my physical activity.I am on medication for seizures or altered mental status.I am not willing or able to follow the birth control requirements of the study.I have another cancer diagnosis such as MDS, leukemia, or an abnormal karyotype.I have consistently followed all treatments and care plans.I stopped taking Oxbryta 30 days ago or Adakveo 3 months ago, with no plans to restart.I've had 2-10 sickle cell crises in the last year, but none in the past month.I do not have a severe illness that could cause death within 6 months.My kidney function is severely impaired.I am a man and cannot follow the study's birth control rules.I need considerable assistance and am unable to carry out any work activities.I am on regular blood transfusions that cannot be stopped for medical reasons.I have not had a blood transfusion in the last 28 days.You have a history of using illegal drugs or drinking alcohol excessively in the past year.I have not had a fever or flu-like symptoms in the last week.
- Group 1: AB1
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Could I possibly qualify to join this clinical trial?
"The key inclusion criteria for this study are anemia, sickle cell, and being between 18-45 years old. Up to 30 patients can be enrolled in total."
Does this research require that study participants be above the age of 18?
"Adults between the ages of 18-45 who meet the other specified inclusion criteria can enroll in this trial. There are 133 clinical trials for individuals under 18 and 85 for seniors aged 65 or older."
Are new volunteers needed for this clinical trial?
"The clinical trial, which was last updated on October 6th, is not currently looking for candidates. This may be due to the fact that it was only posted less than a month ago on November 1st. Although this study isn't recruiting patients right now, there are 202 other studies that are."
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