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Cyclin-Dependent Kinase Inhibitor

Letrozole for Endometrial Adenocarcinoma

Q: How many participants are allowed to register for this research project?

Affirmative. The information on clinicaltrials.gov demonstrates that this research is presently recruiting candidates. This investigation, which was initiated on August 12th 2019, needs 27 participants from two sites to be enrolled.

Q: Has recruitment for this experiment begun?

This clinical trial remains open for recruitment, as per the information on clinicaltrials.gov. This medical study was initially posted to the platform on August 12th 2019 and had its most recent update April 30th 2021.

Q: Has Letrozole been studied and analyzed in other scientific experiments?

Currently, there are 228 clinical trials for Letrozole that have been initiated. Of these studies, 50 are in Phase 3. San Francisco is the most popular location conducting research into this treatment but other sites across America also exist - 15288 to be exact.

Q: In which medical cases is Letrozole generally utilized?

Letrozole is a frequently prescribed therapy for treating <a href="https://www.withpower.com/clinical-trials/breast-cancer">breast cancer</a>, but it has also been effectively used to manage anovulatory cycle and tamoxifen-resistant conditions.

Phase < 1

Waitlist Available

Led By Emma Barber, MD, MS

Research Sponsored by Northwestern University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at day 15

Awards & highlights

Study Summary

This trial is studying how well abemaciclib and letrozole work in treating patients with endometrial cancer.

Eligible Conditions

Endometrial Endometrioid Adenocarcinoma

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at day 15

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at day 15

This trial's timeline: 3 weeks for screening, Varies for treatment, and at day 15 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Changes in Ki-67 expression

Secondary outcome measures

Biological characteristics of tumors: MMR status

Neoplasms

Biological characteristics of tumors: expression of cyclin D1

+4 more

Side effects data

From 2018 Phase 4 trial • 79 Patients • NCT02137538

10%

Fracture

Acne

Scoliosis

Hair loss

Sacroiliitis

Neuro event

100%

80%

60%

40%

20%

Study treatment Arm

Anastrozole

Letrozole

Trial Design

1Treatment groups

Experimental Treatment

Group I: Treatment (letrozole, abemaciclib)Experimental Treatment3 Interventions

Patients receive letrozole PO QD and abemaciclib PO BID on days 1-14. Patients then undergo standard of care hysterectomy on day 15.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Abemaciclib

FDA approved

Letrozole

FDA approved

Therapeutic Conventional Surgery

2005

Completed Phase 3

~9850

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Cancer Institute (NCI)NIH

13,687 Previous Clinical Trials

40,930,344 Total Patients Enrolled

Northwestern UniversityLead Sponsor

1,592 Previous Clinical Trials

918,015 Total Patients Enrolled

Emma Barber, MD, MSPrincipal InvestigatorNorthwestern University

3 Previous Clinical Trials

297 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are allowed to register for this research project?

"Affirmative. The information on clinicaltrials.gov demonstrates that this research is presently recruiting candidates. This investigation, which was initiated on August 12th 2019, needs 27 participants from two sites to be enrolled."

Answered by AI

Has recruitment for this experiment begun?

"This clinical trial remains open for recruitment, as per the information on clinicaltrials.gov. This medical study was initially posted to the platform on August 12th 2019 and had its most recent update April 30th 2021."

Answered by AI

Has Letrozole been studied and analyzed in other scientific experiments?

"Currently, there are 228 clinical trials for Letrozole that have been initiated. Of these studies, 50 are in Phase 3. San Francisco is the most popular location conducting research into this treatment but other sites across America also exist - 15288 to be exact."

Answered by AI

In which medical cases is Letrozole generally utilized?

"Letrozole is a frequently prescribed therapy for treating breast cancer, but it has also been effectively used to manage anovulatory cycle and tamoxifen-resistant conditions."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Abemaciclib and Letrozole in Treating Patients With Endometrial Cancer

2019. "Abemaciclib and Letrozole in Treating Patients With Endometrial Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04049227.