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Alkylating agents

Radiation + Chemotherapy for Endometrial Cancer

Q: How many individuals are being accepted into this medical experiment?

Affirmative, the details on clinicaltrials.gov suggests that this medical trial is currently looking for enrolment. This research was initially shared on January 10th 2023 and subsequently modified two days later. The study requires 28 participants to be recruited from 7 locations.

Q: Are there any available openings for those wanting to take part in the trial?

Correct. Clinicaltrials.gov data demonstrates that this study, which was originally posted on January 10th 2023, is actively searching for participants. This trial requires 28 patients to be recruited from 7 distinct sites.

Q: Has this experiment been implemented in multiple areas of North America?

Presently, 7 locations are actively enrolling patients for this trial. These include Memorial Sloan Kettering Basking Ridge (<a href="https://www.withpower.com/clinical-trials/all">All</a> protocol activities) in Basking Ridge, Memorial Sloan Kettering Bergen (All protocol activities)in Montvale and Memorial Sloan Kettering Commack (All protocol activities)in Commack.

Phase < 1

Recruiting

Led By Kaled Alektair, MD

Research Sponsored by Memorial Sloan Kettering Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

No active infection requiring antibiotics, except for uncomplicated urinary tract infection.

Patients must have newly diagnosed endometrial carcinoma. The following histologic subtypes are eligible for inclusion: endometrioid, serous, clear cell, dedifferentiated/undifferentiated, mixed epithelial, adenocarcinoma not otherwise specified, and carcinosarcoma.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 3 years

Awards & highlights

Study Summary

This trial looks at a shorter radiation treatment with chemo to see if it's practical and can be completed by most patients.

Who is the study for?

This trial is for adults with newly diagnosed endometrial carcinoma who've had specific surgeries and have no residual disease. They must not be breastfeeding, have good organ function, and a performance status indicating they can care for themselves. Excluded are those with certain genetic markers or prior treatments, active infections needing antibiotics (except simple UTIs), or conditions that could affect the trial's safety or results.Check my eligibility

What is being tested?

The study tests if a shorter radiation therapy course (1 week) combined with chemotherapy drugs carboplatin and paclitaxel is feasible for patients to complete compared to the usual 5-week radiation schedule. It aims to see if participants can stick to this condensed treatment plan without significant issues.See study design

What are the potential side effects?

Potential side effects include reactions from radiation like skin irritation and fatigue, as well as chemotherapy-related nausea, hair loss, nerve damage (neuropathy), blood cell count changes increasing infection risk, liver impact shown by altered lab tests, and possible allergic reactions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am not on antibiotics for an infection, except for a simple UTI.

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I have been newly diagnosed with a specific type of endometrial cancer.

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My surgery removed all visible cancer.

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My nerve damage does not significantly affect my daily activities.

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I have not had any treatments for endometrial cancer.

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I am mostly able to care for myself and carry out daily activities.

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I am 18 years old or older.

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I have had surgery that included removal of the uterus, both ovaries, fallopian tubes, and a check of pelvic lymph nodes.

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My condition is in the advanced stage IIIA or IIIC1 according to FIGO 2009.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Feasibility of integrated delivery of short-course IMRT with carboplatin/paclitaxel in patients with stage III endometrial cancer

Trial Design

1Treatment groups

Experimental Treatment

Group I: Participants with Endometrial CancerExperimental Treatment3 Interventions

Participants have stage III endometrial cancer

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Paclitaxel

2011

Completed Phase 4

~5380

Carboplatin

2014

Completed Phase 3

~6670

Intensity-modulated radiation therapy

2006

Completed Phase 3

~1240

0 / 9Eligibility criteria met

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor

1,938 Previous Clinical Trials

588,342 Total Patients Enrolled

19 Trials studying Endometrial Cancer

4,452 Patients Enrolled for Endometrial Cancer

Kaled Alektair, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center

Media Library

Carboplatin (Alkylating agents) Clinical Trial Eligibility Overview. Trial Name: NCT05691010 — Phase < 1

Endometrial Cancer Research Study Groups: Participants with Endometrial Cancer

Endometrial Cancer Clinical Trial 2023: Carboplatin Highlights & Side Effects. Trial Name: NCT05691010 — Phase < 1

Carboplatin (Alkylating agents) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05691010 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are being accepted into this medical experiment?

"Affirmative, the details on clinicaltrials.gov suggests that this medical trial is currently looking for enrolment. This research was initially shared on January 10th 2023 and subsequently modified two days later. The study requires 28 participants to be recruited from 7 locations."

Answered by AI

Are there any available openings for those wanting to take part in the trial?

"Correct. Clinicaltrials.gov data demonstrates that this study, which was originally posted on January 10th 2023, is actively searching for participants. This trial requires 28 patients to be recruited from 7 distinct sites."

Answered by AI

Has this experiment been implemented in multiple areas of North America?

"Presently, 7 locations are actively enrolling patients for this trial. These include Memorial Sloan Kettering Basking Ridge (All protocol activities) in Basking Ridge, Memorial Sloan Kettering Bergen (All protocol activities)in Montvale and Memorial Sloan Kettering Commack (All protocol activities)in Commack."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Study of Short-Course Radiation Therapy With Chemotherapy in People With Endometrial Cancer

2023. "A Study of Short-Course Radiation Therapy With Chemotherapy in People With Endometrial Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05691010.

All > Endometrial Cancer