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Estradiol Patch for Post-Traumatic Stress Disorder
Study Summary
This trial will test the effects of estradiol on PTSD symptoms and stress vulnerability in three groups of women.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2021 Phase 1 trial • 12 Patients • NCT03681691Trial Design
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Who is running the clinical trial?
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- I have had a blood clot in the past.I am currently using hormone-based birth control or taking hormonal supplements.You have had a serious head injury or have a neurological disorder in your medical history.I am currently experiencing symptoms of psychosis or bipolar disorder.I weigh less than or equal to 250lbs and do not have metal implants.I have a smartphone and am willing to install the Clue app.I have a condition that causes my blood to clot more than normal.I am an African American woman.I am not pregnant or breastfeeding.I am currently taking medication for my mental health.You are currently using nicotine products or smoking.
- Group 1: Cohort 2: Trauma Control Receiving Placebo then Estradiol
- Group 2: Cohort 1: Healthy Controls Receiving Placebo then Estradiol
- Group 3: Cohort 2: Trauma Control Receiving Estradiol, then Placebo
- Group 4: Cohort 2: Healthy Control Receiving Estradiol then Placebo
- Group 5: Cohort 2: PTSD Receiving Estradiol then Placebo
- Group 6: Cohort 2: PTSD Receiving Placebo then Estradiol
- Group 7: Cohort 2: Healthy Control Receiving Placebo then Estradiol
- Group 8: Cohort 1: PTSD Receiving Estradiol then Placebo
- Group 9: Cohort 1: PTSD Receiving Placebo then Estradiol
- Group 10: Cohort 1: Trauma without PTSD Receiving Estradiol then Placebo
- Group 11: Cohort 1: Trauma without PTSD Receiving Placebo then Estradiol
- Group 12: Cohort 1: Healthy Controls Receiving Estradiol then Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is admission to this investigation still open?
"Affirmative. Clinicaltrials.gov attests to the current recruitment status of this trial, which was initially posted on November 11th 2019 and recently updated February 17th 2022. The study requires 240 participants sourced from a single site."
How many individuals are currently being monitored as part of this research endeavor?
"Affirmative. Information available on clinicaltrials.gov implies that this medical research is actively seeking participants, having been initially posted on November 11th 2019 and most recently updated February 17th 2022. The trial requires the enrolment of 240 patients from 1 site."
Does this research encompass participants who are of advanced age?
"This trial is only open to patients aged 18-35, while those younger and older have their own clinical trials; 51 for the former and 307 for the latter."
To what end is Estradiol patch typically utilized?
"A lack of menstruation for the prior 6 months, a deficiency in estrogen levels, and associated menopausal symptoms can be managed through Estradiol patch therapy."
Who would qualify for inclusion in this research endeavor?
"This medical trial is recruiting 240 volunteers between the ages of 18 and 35, all of whom currently suffer from post traumatic stress disorder (PTSD). In addition to these criteria, participants must also be African American women with access to a smartphone who are willing to install the Clue application."
Who else is applying?
What state do they live in?
How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
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