Cancer Cachexia for Colorectal, Lung, and Pancreatic Cancer
(LOTUS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to learn more about cancer cachexia, a condition marked by weight, muscle, and fat loss in people with certain cancers. The study observes patients with advanced colorectal, lung, or pancreatic cancer to understand how cachexia affects them and how it might be treated more effectively in the future. Participants will complete surveys, undergo physical tests, provide blood samples, and wear a device to track daily activity. Patients with colorectal, lung, or pancreatic cancer that cannot be removed by surgery, and who are starting or have recently started cancer treatment, are suitable candidates for this study. As an unphased trial, this study offers patients the opportunity to contribute to foundational research that may improve future treatments for cancer cachexia.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to uncover subtypes of cancer cachexia, a condition where patients experience severe weight loss and muscle wasting. Unlike traditional treatments that mainly focus on managing symptoms, this study uses a combination of surveys, physical tests, blood samples, and actigraphs to gather a comprehensive set of data over time. By analyzing this data, researchers hope to identify distinct subtypes of cachexia, which could lead to more personalized and effective future treatments. This approach is unique because it prioritizes understanding the underlying mechanisms of the condition, rather than just addressing the symptoms.
Who Is on the Research Team?
Richard F Dunne
Principal Investigator
University of Rochester NCORP Research Base
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants complete surveys, undergo physical function tests, collection of blood and archived tumor samples, and wear actigraph for 7 days
3-Month Follow-up
Participants undergo follow-up assessments including surveys, physical function tests, and actigraph monitoring
1-Year Follow-up
Participants' medical records are reviewed and standard of care PET/CT scans are conducted
What Are the Treatments Tested in This Trial?
Interventions
- Observational Research Study
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients complete surveys over 30 minutes, undergo physical function tests over 30 minutes, undergo collection of blood and archived tumor samples, and wear actigraph over 24 hours for 7 days to record daily sleep and exercise activity at baseline and 3-month follow-up. Additionally, patients undergo standard of care CT or PET/CT scans throughout the study and patients' medical records are also reviewed at baseline, 3-month and 1-year follow-up.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Rochester
Lead Sponsor
University of Rochester NCORP Research Base
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.