300 Participants Needed

Motion Perception Study for Vestibular Disorders

KC
CA
Overseen ByCesar Arduino
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Rochester
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 1 JurisdictionThis treatment is already approved in other countries

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Heading direction adaptation, Heading Perception Adaptation, Directional Adaptation Therapy for vestibular disorders?

Research shows that multisensory visual-vestibular training can improve visual heading perception, especially in older adults, by enhancing their ability to judge direction. This suggests that similar training methods could be effective in treating vestibular disorders by improving self-motion perception.12345

Is the treatment for vestibular disorders generally safe for humans?

The smartphone-based system for vestibular rehabilitation was found to be safe and usable, with minimal symptoms reported by healthy subjects, though patients with vestibular conditions experienced more symptoms, likely due to their condition.678910

How does this treatment for vestibular disorders differ from other treatments?

This treatment is unique because it uses a tactile sway feedback device to help balance and recovery, which is derived from aeromedical research and is not commonly used in standard vestibular disorder treatments. It focuses on mitigating imbalance by providing real-time feedback to the user, which is different from traditional therapies that may not offer such immediate and adaptive support.1561112

What is the purpose of this trial?

The purpose this study is to measure sensitivity to visual and vestibular or balance motion. It is hoped that the results may help researchers better understand how aging and disease affect motion perception.

Eligibility Criteria

This study is for people in good health who have lost some or all of their vestibular function, which affects balance, on one or both sides. It aims to understand how aging and diseases impact the way we perceive motion.

Inclusion Criteria

I have hearing loss in one or both ears.
You are in overall good health.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo visual and vestibular motion perception tests to measure sensitivity and adaptation

1 week
Multiple sessions for testing and adaptation

Follow-up

Participants are monitored for changes in heading perception and dizziness symptoms

4 weeks

Treatment Details

Interventions

  • Heading direction adaptation
Trial Overview The trial is testing 'Heading direction adaptation' to see how it influences visual and balance-related motion perception. Participants will undergo tests that measure their sensitivity to movement.
Participant Groups
2Treatment groups
Active Control
Group I: Healthy subjectsActive Control1 Intervention
Group II: Vestibular Disease patientsActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Rochester

Lead Sponsor

Trials
883
Recruited
555,000+

National Institute on Deafness and Other Communication Disorders (NIDCD)

Collaborator

Trials
377
Recruited
190,000+

Findings from Research

Astronauts and vestibular patients experience similar challenges in orientation due to changes in how they process acceleration stimuli, suggesting that research methods for one group could benefit the other.
Two promising ground-based strategies were introduced: one for assessing vestibular adaptation-induced imbalance through a temporary disruption in healthy subjects, and another involving a tactile feedback device aimed at improving balance recovery for those with vestibular issues, both of which need further evaluation in clinical and astronaut settings.
The Neurovestibular Challenges of Astronauts and Balance Patients: Some Past Countermeasures and Two Alternative Approaches to Elicitation, Assessment and Mitigation.Lawson, BD., Rupert, AH., McGrath, BJ.[2020]
A study involving 19 subjects (9 in the experimental group and 10 in the control group) found no evidence that adaptation to head movements in the yaw plane transfers to head movements in the pitch plane, indicating that the brain adapts to vestibular stimuli in a plane-specific manner.
These findings suggest that for effective adaptation to cross-coupled stimuli, such as those experienced in spaceflight, astronauts will need to practice head movements in all planes and directions, rather than relying on adaptation from one plane to another.
Vestibular adaptation to centrifugation does not transfer across planes of head rotation.Garrick-Bethell, I., Jarchow, T., Hecht, H., et al.[2008]
Training that combines visual and vestibular feedback can significantly improve visual-only self-motion heading perception in older adults, with 27% of participants who initially struggled able to achieve similar performance levels to younger adults after training.
While older adults showed optimal integration of sensory information both before and after training, younger adults only reached this level of integration after the training, suggesting that older adults may benefit more from targeted interventions to enhance their perceptual abilities.
Multisensory visual-vestibular training improves visual heading estimation in younger and older adults.Gabriel, GA., Harris, LR., Henriques, DYP., et al.[2022]

References

The Neurovestibular Challenges of Astronauts and Balance Patients: Some Past Countermeasures and Two Alternative Approaches to Elicitation, Assessment and Mitigation. [2020]
Vestibular adaptation to centrifugation does not transfer across planes of head rotation. [2008]
Multisensory visual-vestibular training improves visual heading estimation in younger and older adults. [2022]
Psychophysical Evaluation of Sensory Reweighting in Bilateral Vestibulopathy. [2020]
Dual adaptation of apparent concomitant motion contingent on head rotation frequency. [2019]
Human vestibular perceptual thresholds - A systematic review of passive motion perception. [2023]
How much I moved: Robust biases in self-rotation perception. [2022]
The Impact of Oral Promethazine on Human Whole-Body Motion Perceptual Thresholds. [2022]
A Smartphone-based gaming system for vestibular rehabilitation: A usability study. [2020]
Evaluation of effects of optokinetic and rotational stimuli with functional head impulse test (fHIT) in individuals with motion sickness. [2023]
Symptoms elicited in persons with vestibular dysfunction while performing gaze movements in optic flow environments. [2021]
12.United Statespubmed.ncbi.nlm.nih.gov
Vertigo and dizziness from environmental motion: visual vertigo, motion sickness, and drivers' disorientation. [2022]
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