Clinical Transcriptomics for Vasculitis
(CUTIS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial focuses on understanding skin changes in individuals with various types of vasculitis, a condition characterized by inflamed blood vessels. Researchers aim to study skin lesions, such as purplish spots or nodules, to gain insights into how these conditions affect the body at a cellular level. As an observational study, no treatment will be administered; researchers will only collect information. Candidates may be suitable if they have a skin lesion that a doctor suspects is related to vasculitis and have one of several specific types, such as IgA vasculitis or drug-induced vasculitis. As an unphased trial, this study provides a unique opportunity to contribute to scientific understanding without undergoing treatment.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
Why are researchers excited about this trial?
Researchers are excited about the CUTIS trial because it uses clinical transcriptomics to explore systemic vasculitis in a completely new way. Unlike traditional treatments that focus on managing symptoms with medications like corticosteroids or immunosuppressants, this approach aims to understand the disease at the genetic level. By analyzing gene expression in patients, scientists hope to uncover specific biomarkers and pathways that could lead to more targeted and effective therapies. This could revolutionize how we diagnose and treat systemic vasculitis, potentially leading to personalized treatment plans tailored to each patient's unique genetic makeup.
Who Is on the Research Team?
Robert Micheletti, MD
Principal Investigator
University of Pennsylvania
Peter Grayson, MD, MSc
Principal Investigator
The National Institute of Arthritis and Musculoskeletal and Skin Diseases
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Evaluation
Patients with cutaneous manifestations of vasculitis are evaluated by primary vasculitis care providers and Dermatologists for optimal selection and sampling of lesions.
Biopsy and Analysis
A punch skin biopsy at a site of active vasculitis is performed for histopathologic and transcriptomic evaluation.
Follow-up
Participants are monitored for safety and effectiveness after biopsy and analysis.
What Are the Treatments Tested in This Trial?
Interventions
- Observational Study
Find a Clinic Near You
Who Is Running the Clinical Trial?
Peter Merkel
Lead Sponsor
Office of Rare Diseases Research (ORDR)
Collaborator
National Center for Advancing Translational Sciences (NCATS)
Collaborator
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborator
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