Surgical Approaches for Total Knee Replacement

TL
Overseen ByThomas L Bradbury, M.D.
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Total Joint Specialists
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a single-institution, prospective, randomized study comparing the medial parapatellar and subvastus approaches in primary total knee arthroplasty using continuous, implant-based gait monitoring. Patients receiving a Zimmer Persona IQ smart implant will be followed preoperatively and through the first 30 days post-operatively, with extended follow-up to 6 months. Preoperative activity is captured using iPhone Health step-count data, while post-operative recovery is assessed using continuous tibial implant data, including step count, range of motion, cadence, walking speed, stride length, and distance. These objective metrics are correlated with PROMs. The primary outcome is daily step count. Secondary outcomes include early functional milestones, pain, and patient-reported functional scores. This study is designed to characterize early recovery trajectories and determine whether meaningful differences exist between surgical approaches.

Are You a Good Fit for This Trial?

This trial is for individuals undergoing total knee replacement who will receive a Zimmer Persona IQ smart implant. Participants should be able to use an iPhone preoperatively and commit to follow-up for at least 6 months post-surgery. Specific eligibility criteria are not provided, but typically include adults in need of the surgery with no major health issues that would interfere with recovery or data collection.

Inclusion Criteria

I am over 18 and planning to have a specific knee replacement surgery.
I have an iPhone and agree to use it to track my steps for two weeks before surgery.
Provide informed consent
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Exclusion Criteria

My knee can't fully straighten or bend properly.
I have had a knee replacement revision.
Patients with TKA other than medial congruent polyethylene bearing
See 6 more

What Are the Treatments Tested in This Trial?

Interventions

  • Total Knee Arthroplasty Medial Parapatellar Approach
  • Total Knee Arthroplasty Subvastus Approach

Trial Overview

The study compares two surgical techniques for knee replacement: medial parapatellar and subvastus approaches. It uses a smart implantable device to monitor patients' gait and activity levels before and after surgery, aiming to assess which approach leads to better early recovery based on step count, range of motion, walking speed, stride length, distance walked, pain levels, and patient-reported outcomes.

How Is the Trial Designed?

2

Treatment groups

Active Control

Group I: Subvastus ApproachActive Control1 Intervention
Group II: Medial Parapatellar ApproachActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Total Joint Specialists

Lead Sponsor