Thyroid Artery Embolization for Goiter
(TAE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new method to treat goiters (enlarged thyroid glands) that press on the windpipe or food pipe, causing discomfort. The treatment under investigation, Thyroid Artery Embolization (TAE), aims to reduce the goiter's size without surgery. Individuals with goiters causing pressure symptoms who cannot or prefer not to undergo surgery might be suitable candidates. The trial will assess the safety and effectiveness of this treatment for those needing an alternative to traditional options. As an unphased trial, it offers patients a chance to explore a non-surgical treatment that could enhance their quality of life.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this technique is safe for treating goiter with compressive symptoms?
Research has shown that thyroid artery embolization (TAE) is generally safe for treating goiters, which are enlarged thyroid glands. One study found no major complications in patients up to six months after the procedure. Another study demonstrated that TAE reduced the size of the goiter and relieved symptoms like neck pressure, without any serious side effects. Additionally, evidence from other studies suggests that TAE can shrink the thyroid gland by 40% to 70% and improve thyroid function, especially in those with an overactive gland. Overall, TAE appears to be a well-tolerated option for managing goiters, particularly for those who cannot or choose not to undergo standard treatments.12345
Why are researchers excited about this trial?
Thyroid Artery Embolization is unique because it offers a non-surgical alternative for treating goiter, especially when traditional options like surgery or hormone therapy are not suitable or desired by the patient. This procedure works by blocking blood flow to the thyroid, which can shrink the goiter and relieve compressive symptoms without the need for invasive surgery. Researchers are excited because it provides a less invasive option with potentially fewer risks and quicker recovery times compared to the standard surgical interventions.
What evidence suggests that Thyroid Artery Embolization is effective for treating compressive goiters?
Research has shown that thyroid artery embolization (TAE), a procedure participants in this trial will undergo, might effectively treat goiters causing pressure or discomfort. Studies have found that TAE can reduce goiter size and alleviate symptoms with few side effects. For individuals with conditions like toxic goiter or recurrent goiters, TAE has proven safe and potentially beneficial. Early results suggest that TAE might also reduce thyroid nodules and improve outcomes if surgery becomes necessary later. Although evidence remains limited, the procedure appears promising for those unable or unwilling to pursue traditional treatments.23456
Are You a Good Fit for This Trial?
This trial is for adults with goiters causing compression symptoms who can't have or don't want surgery. They must have had certain biopsy results (Bethesda I/III twice, or II once) and a TiRADS score of 1-4. People with the highest risk thyroid nodules (TiRADS 5), severe hyperthyroidism, conditions that make endovascular procedures unsafe, or minors cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo Thyroid Artery Embolization (TAE) for the treatment of compressive goiters
Follow-up
Participants are monitored for safety and effectiveness after TAE with follow-ups at 1 week, 3 months, 6 months, and 12 months
What Are the Treatments Tested in This Trial?
Interventions
- Thyroid Artery Embolization
Trial Overview
The study tests Thyroid Artery Embolization (TAE) as a treatment for compressive goiters in patients who are not candidates for surgery. It's an observational study to standardize imaging and follow-up to assess TAE's effectiveness and safety.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients with diagnosis of Goiter with compressive symptoms in which other alternatives lack or are refused by the patient himself.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Université de Sherbrooke
Lead Sponsor
Citations
Comparison of Clinical Outcomes of Thyroid Artery ... - PMC
Current data supports its efficacy in patients with toxic goiter, recurrent goiter, Graves' disease (GD), and thyroid carcinoma [1, 3].
Thyroid Arterial Embolization for the Management of ...
The primary outcome was safety and efficacy. Limited evidence suggested benefits, including goiter size reduction and symptom relief with minimal complications ...
Comparison of Clinical Outcomes of Thyroid Artery ...
Conclusion: TAE appears to be a safe and potentially effective procedure for reducing thyroid nodule volume and improving surgical outcomes.
Abstract No. 216 Safety and Efficacy of Thyroid Artery ...
Thyroid artery embolization is a safe and efficacious procedure for treatment of MNG with no major complications seen up to 6-month follow up.
Thyroid Artery Goitre Embolization Trial A Pilot Study ...
We will also collect additional data (for example on pain, effectiveness, cost and health related quality of life) to inform a future larger trial comparing TAE ...
Safety and Efficacy of Pressure-Enabled Thyroid Embolization
A recent study evaluating the safety and efficacy of TAE in patients with nodular goiter demonstrated promising outcomes [1]. The aforementioned study achieved ...
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