EMG vs AMG Devices for Surgery

(PEARL Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Mayo Clinic
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to compare the mean cumulative weight-based/time-corrected rocuronium dose administered in patients undergoing robotic- or laparoscopic- assisted surgery using either acceleromyography or electromyography.

Who Is on the Research Team?

JR

Johnathan Renew

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

Inclusion Criteria

I am willing to join the study and give my informed consent.
I am scheduled for an elective laparoscopic or robotic surgery.
My planned surgery will take less than 5 hours.
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Exclusion Criteria

I have chronic kidney disease with reduced kidney function.
Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury
Patients with systemic neuromuscular diseases such as myasthenia gravis
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Perioperative/Periprocedural

Participants undergo robotic- or laparoscopic-assisted surgery with neuromuscular block management using either EMG or AMG

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after surgery

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Robotic/Laparoscopic Surgery

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Active Control

Group I: AMGExperimental Treatment1 Intervention
Group II: EMGActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+