500 Participants Needed

ENDS Prevention for E-Cigarette Use

SK
Overseen ByScott K Okamoto, PhD
Age: < 18
Sex: Any
Trial Phase: Academic
Sponsor: University of Hawaii
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The purpose of this research proposal is to develop and evaluate a culturally grounded, ENDS prevention intervention for rural Hawaiian youth. This will be accomplished through two specific aims. AIM 1 (Years 1-3) are focused on pre-intervention and intervention development. In Year 1, youth focus groups will be conducted to assess the environmental demands related to ENDS use in rural Hawai'i. In Year 2, specific ENDS-related problem situations (i.e., situations that increase risk for ENDS use) will be extracted from the Year 1 focus groups and prioritized through survey methods with 200-250 predominately Native Hawaiian youth across 16 different middle/intermediate schools on Hawai'i Island. In Year 3, five situations found to be the most frequently experienced and/or difficult to manage by youth surveyed in Year 2 will serve as the foundation for the development of narrative scripts. Three of these scripts will be cast and filmed on location on Hawai'i Island by a professional film director, and will be edited into three short films, 6-8 video clips, and 6-8 professional photos or production stills. Similar to the investigators' prior drug prevention research in rural Hawai'i, classroom-based lessons will be created to support the short films. Additional lessons and videos from an evidence-based, culturally grounded substance abuse prevention curriculum for Hawaiian youth (Ho'ouna Pono) will be used to create a modular classroom curriculum. The video clips and professional photography/production stills will be embedded with prevention messaging, and will be used for a social and print media campaign to reinforce the classroom curriculum. AIM 2 (Years 4-5) is to evaluate the ENDS prevention intervention (classroom curriculum plus social/print media campaign) across all middle/intermediate public or public-charter schools (N = 16) and up to 11 different cultural immersion charter schools on Hawai'i Island using a dynamic wait-listed control group design.

Will I have to stop taking my current medications?

The trial information does not specify whether participants need to stop taking their current medications.

What data supports the effectiveness of the ENDS Prevention Intervention treatment?

The research highlights that many users of electronic nicotine delivery systems (ENDS) are interested in quitting, with over 10% attempting to quit in the past year and 60% planning to quit in the future. This suggests that interventions aimed at preventing or reducing ENDS use could be effective, as there is a significant interest in cessation among users.12345

Is the ENDS Prevention Intervention generally safe for humans?

The safety of electronic nicotine delivery systems (ENDS) is still being studied, and there are concerns about their potential harmful effects, especially for young people and pregnant women. While some believe ENDS might help reduce smoking risks, definitive safety data is lacking, and more research is needed to understand their health impacts.13678

How is the ENDS Prevention Intervention treatment different from other treatments for e-cigarette use?

The ENDS Prevention Intervention is unique because it focuses on preventing the use of electronic nicotine delivery systems (e-cigarettes) rather than treating existing use, which is a novel approach compared to other treatments that typically address cessation. This intervention is particularly important as it targets young people and non-smokers who are increasingly using e-cigarettes, a group for whom these products were not originally intended.1391011

Eligibility Criteria

This trial is for rural Hawaiian youth, primarily Native Hawaiian, who are attending middle or intermediate schools on Hawai'i Island. It aims to prevent the use of electronic nicotine delivery systems (ENDS), commonly known as e-cigarettes.

Inclusion Criteria

I am a student in grades 6-8 at a public or charter school on Hawaii Island.

Exclusion Criteria

I am a student in K-5th or 9th-12th grade on Hawaii Island.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Pre-intervention and Intervention Development

Focus groups and surveys are conducted to develop and prioritize ENDS-related problem situations and create narrative scripts and classroom lessons.

3 years

Efficacy Trial

The ENDS prevention intervention is evaluated using a dynamic wait-listed control group design across participating schools.

2 years

Follow-up

Participants are monitored for the effectiveness of the intervention with follow-up evaluations at various intervals post-intervention.

Up to 15 months

Treatment Details

Interventions

  • ENDS Prevention Intervention
Trial Overview The intervention being tested includes a classroom curriculum supported by short films and video clips that address situations increasing the risk for ENDS use. Additionally, a social and print media campaign will reinforce the prevention messages from these materials.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: ENDS Prevention InterventionExperimental Treatment1 Intervention
Participants will receive the ENDS Prevention Intervention consisting of (1) a modular classroom curriculum, (2) social media content, and (3) print media campaign.
Group II: Treatment-as-usual controlActive Control1 Intervention
Participants will receive treatment-as-usual, which consists of the standard health curriculum delivered in public schools.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Hawaii

Lead Sponsor

Trials
122
Recruited
55,200+

University of California, Riverside

Collaborator

Trials
33
Recruited
14,400+

Findings from Research

Electronic nicotine delivery systems (ENDS), like e-cigarettes, were introduced as a safer alternative for smokers, but their use has expanded to young people and non-smokers, raising concerns about unintended health risks.
The design and power of ENDS devices can significantly affect their safety, with higher power devices potentially being more hazardous, highlighting the need for ongoing research to understand the benefits and risks associated with these products.
Clearing the Haze: What Do We Still Need to Learn about Electronic Nicotine Delivery Systems?Fucito, LM., Malinosky, H., Baldassarri, SR., et al.[2023]
Electronic nicotine delivery systems (ENDS), like e-cigarettes, have rapidly increased in use among both adults and youth, raising concerns about their potential to either help reduce smoking rates or inadvertently encourage tobacco use among non-smokers and former smokers.
The American Association for Cancer Research (AACR) and the American Society of Clinical Oncology (ASCO) emphasize the need for more research on ENDS to understand their health impacts and recommend strict regulations, including childproof packaging and prohibiting youth-targeted marketing, to mitigate potential risks.
Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology.Brandon, TH., Goniewicz, ML., Hanna, NH., et al.[2022]

References

Clearing the Haze: What Do We Still Need to Learn about Electronic Nicotine Delivery Systems? [2023]
Factors associated with past-year attempts to quit e-cigarettes among current users: Findings from the Population Assessment of Tobacco and Health Wave 4 (2017-2018). [2023]
Trajectories of ENDS and cigarette use among dual users: analysis of waves 1 to 5 of the PATH Study. [2023]
Vaping: Impact of Improving Screening Questioning in Adolescent Population: A Quality Improvement Initiative. [2022]
A scoping review of studies on the health impact of electronic nicotine delivery systems. [2022]
Are electronic nicotine delivery systems helping cigarette smokers quit? Evidence from a prospective cohort study of U.S. adult smokers, 2015-2016. [2022]
Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology. [2022]
Electronic Nicotine Delivery Systems (ENDS) Use and Pregnancy II: Perinatal Outcomes Following ENDS Use During Pregnancy. [2022]
Electronic nicotine delivery systems: executive summary of a policy position paper from the American College of Physicians. [2019]
Trends in use of electronic nicotine delivery systems by adolescents. [2021]
11.United Statespubmed.ncbi.nlm.nih.gov
Key Risk Factors Associated With Electronic Nicotine Delivery Systems Use Among Adolescents. [2023]
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