Alpha Brain for Sleep Deprivation

Overseen By Gabe Wilson, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Applied Science & Performance Institute

Must not be taking: Sleep medicines, Melatonin

Disqualifiers: Cognitive impairment, Cardiovascular disease, Anxiety, Sleep disorders, others

Compensation: Varies

Number of Visits: 3

Duration: 3 visits with a minimum 3-day washout period between each

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this randomized, double-blind, placebo-controlled crossover study is to evaluate the efficacy of the acute effects of an investigational supplement (Alpha Brain or Alpha Brain 2.0) on improving cognitive performance, vigilance, and subjective mood in healthy adults compared to placebo during a period of acute sleep deprivation under conditions of controlled sleep deprivation.

Who Is on the Research Team?

Eric Sikorski, PhD

Principal Investigator

Applied Science and Performance Institute

Are You a Good Fit for This Trial?

Inclusion Criteria

Willingness to meet all study requirements and restrictions. Including willing to arrive in lab in a sleep deprived state (≤ or =5 hours), willing to avoid alcohol consumption 72 hours prior to testing days, and willing to avoid caffeine within 12 hours prior to testing days.

I am willing to keep my usual diet and habits during the study.

I am healthy and between 20 and 59 years old.

Exclusion Criteria

I currently have a fever or cold-like symptoms.

History of anxiety disorders

I have not consumed alcohol for at least 72 hours before and during the study days.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants undergo three experimental conditions: Alpha Brain, Alpha Brain 2.0, and placebo, each separated by a minimum 3-day washout period. Cognitive testing, mood assessments, and safety monitoring are conducted following overnight sleep restriction.

3 visits with a minimum 3-day washout period between each

3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Alpha Brain
• Alpha Brain 2.0

How Is the Trial Designed?

Group I: Alpha Brain Experimental Treatment 1 Intervention

Alpha Brain investigational dietary supplement administered as two oral capsules with water

Group II: Alpha Brain 2.0 Active Control 1 Intervention

Alpha Brain 2.0 investigational dietary supplement administered as two oral capsules with water

Group III: Control Treatment Placebo Group 1 Intervention

Inactive/inert placebo capsules administered as two oral capsules with water

Who Is Running the Clinical Trial?

Applied Science & Performance Institute

Lead Sponsor

Trials

17

Recruited

1,200+