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Brain Stimulation

Brain Stimulation for Schizophrenia

N/A
Recruiting
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of schizophrenia, schizophreniform or schizoaffective disorder
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up assessment will begin immediately following stimulation and last for about 1.5 hours.
Awards & highlights

Study Summary

This trial is studying how well transcranial direct current stimulation (tDCS) works in improving higher-order cognition in people with and without schizophrenia.

Who is the study for?
This trial is for adults with schizophrenia, schizophreniform or schizoaffective disorder who have stable mental health, no recent medication changes, and a normal IQ. They must not be on clozapine, pregnant, have uncorrected vision issues that affect testing or skin conditions at electrode sites. Participants should not have substance abuse history in the last month or metal implants.Check my eligibility
What is being tested?
The study tests how brain function related to higher-order cognition (like language comprehension and memory) is affected by transcranial direct current stimulation (tDCS). It compares the effects of tDCS on different brain regions using behavioral tasks and EEG monitoring in both healthy individuals and those with schizophrenia.See study design
What are the potential side effects?
Potential side effects from tDCS may include discomfort at the electrode site, itching, tingling during application, headache after treatment sessions, fatigue or nausea. Serious risks are rare but can include seizures or skin burns.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
You have been diagnosed with schizophrenia, schizophreniform or schizoaffective disorder.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~assessment will begin immediately following stimulation and last for about 1.5 hours.
This trial's timeline: 3 weeks for screening, Varies for treatment, and assessment will begin immediately following stimulation and last for about 1.5 hours. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Behavioral Response (Cognitive Control Task)
Behavioral Response (Language Task)
EEG Correlates of Language and Cognitive Control

Side effects data

From 2021 Phase 2 & 3 trial • 160 Patients • NCT02483468
2%
skin irritation
2%
Car accident
100%
80%
60%
40%
20%
0%
Study treatment Arm
tDCS (Active)
tDCS (Sham)

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: DLPFC StimulationExperimental Treatment1 Intervention
Intervention. 20 minutes of 2 mA direct current stimulation over the dorsolateral prefrontal cortex.
Group II: Occipital StimulationActive Control1 Intervention
Intervention. 20 minutes of 2 mA direct current stimulation over the occipital cortex.
Group III: Sham StimulationPlacebo Group1 Intervention
Placebo Comparator. 0.5-1 minutes of 2 mA direct current stimulation over the dorsolateral prefrontal cortex followed by 19-19.5 minutes of sham stimulation
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial Direct Current Stimulation
2014
Completed Phase 3
~1100

Find a Location

Who is running the clinical trial?

University of California, DavisLead Sponsor
908 Previous Clinical Trials
4,703,995 Total Patients Enrolled
3 Trials studying Schizophrenia
181 Patients Enrolled for Schizophrenia

Media Library

Transcranial Direct Current Stimulation (Brain Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT03814967 — N/A
Schizophrenia Research Study Groups: DLPFC Stimulation, Sham Stimulation, Occipital Stimulation
Schizophrenia Clinical Trial 2023: Transcranial Direct Current Stimulation Highlights & Side Effects. Trial Name: NCT03814967 — N/A
Transcranial Direct Current Stimulation (Brain Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03814967 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the eligibility requirements for participating in this trial?

"This clinical trial can accept up to 120 individuals aged between 18 and 35 that have been diagnosed with schizophrenia. To be eligible, they must not plan on altering their medication in the upcoming month, are not using clozapine as an antipsychotic drug, remain stable while being treated either partially or out-patiently, and had no changes in medications during the past month."

Answered by AI

What is the uppermost participant limit for this clinical trial?

"Confirmed. Clinicaltrials.gov outlines the commencement date of this study on May 22nd 2019, with a recent edit to the trial posted on January 25th 2022. The research is seeking 120 clinical participants from one centre."

Answered by AI

Is eligibility for this experiment restricted to individuals younger than 55 years old?

"As listed in the study's inclusion criteria, only individuals between 18 and 35 years old are eligible to participate."

Answered by AI

Are there still opportunities to join this research experiment?

"Per the information accessible on clinicaltrials.gov, this trial is currently recruiting suitable participants. It was originally posted to the website on May 22nd 2019 and last updated on January 25th 2022."

Answered by AI

Who else is applying?

What state do they live in?
North Carolina
How old are they?
65+
What portion of applicants met pre-screening criteria?
Did not meet criteria
~21 spots leftby Mar 2025