Ventilation Strategies for Cardiac Arrest
(OPTIVO Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
When the heart stops pumping during cardiac arrest, cardiopulmonary resuscitation (CPR) is used to continue pushing blood and providing oxygen to vital organs. CPR involves a combination of chest compressions (to push the blood) and ventilations (to provide oxygen and gas exchange). There is a lot of research that has helped to optimize the provision of chest compressions, however there is considerably less research available to guide ventilations. The current guideline recommendations are based on limited data, and no data that is specific to cardiac arrest patients. There is a recognized need for research to better guide ventilation during CPR. This research will help to better define appropriate ventilation targets for cardiac arrest patients.
Who Is on the Research Team?
Ian Drennan, PhD
Principal Investigator
Sunnybrook Health Sciences Centre
Sheldon Cheskes, MD
Principal Investigator
Sunnybrook Health Sciences Centre
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive ventilation interventions during cardiac arrest with real-time feedback
Follow-up
Participants are monitored for survival to hospital admission and discharge
What Are the Treatments Tested in This Trial?
Interventions
- High Volume Ventilation
- Low Volume Ventilation
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Find a Clinic Near You
Who Is Running the Clinical Trial?
Sunnybrook Health Sciences Centre
Lead Sponsor
Zoll Medical Corporation
Industry Sponsor
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