What side effects are associated with this type of intervention?

The most common treatments for Rapid Sequence Intubation (RSI) involve the use of sedatives such as etomidate or propofol, and neuromuscular blocking agents like succinylcholine or rocuronium. Known side effects of these medications include hypotension and adrenal suppression with etomidate, cardiovascular depression with propofol, hyperkalemia and malignant hyperthermia with succinylcholine, and prolonged paralysis with rocuronium. Standardization and protocolization of RSI aim to minimize these risks by ensuring appropriate dosing and monitoring.

What prior FDA approvals exist?

Rapid Sequence Intubation (RSI) involves the use of sedative and paralytic agents to facilitate quick and safe intubation. FDA-approved sedatives commonly used in RSI include etomidate, propofol, and midazolam. For paralytics, succinylcholine and rocuronium are frequently used. These medications help in rapidly inducing unconsciousness and muscle relaxation, allowing for the swift and controlled insertion of an endotracheal tube.

What other types of research exist?

Promising novel alternatives to Rapid Sequence Intubation (RSI) include the use of video laryngoscopy, which provides better visualization of the airway, and supraglottic airway devices like the laryngeal tube disposable (LT-D), which can rapidly and effectively secure the airway with reduced 'no-flow-time.' These alternatives are gaining traction due to their potential to improve outcomes and streamline the intubation process.

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Intubation Checklist for Rapid Sequence Intubation

N/A

Recruiting

Led By Josesph Roarty, MD

Research Sponsored by Community Medical Center, Toms River, NJ

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at time of intubation

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to improve the safety and success of inserting breathing tubes in emergency patients by using a step-by-step checklist. The checklist helps medical staff follow all necessary steps, reducing mistakes and complications.

Who is the study for?

This trial is for any patient who needs an endotracheal intubation in the Emergency department. It's not open to individuals under 18 years old.

What is being tested?

The study is testing whether using a checklist during rapid sequence intubation improves the quality and standardization of care compared to the usual procedures without a checklist.

What are the potential side effects?

Since this trial focuses on process improvement rather than medication, it doesn't have typical drug side effects. However, risks may include those generally associated with endotracheal intubation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at time of intubation

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at time of intubation

This trial's timeline: 3 weeks for screening, Varies for treatment, and at time of intubation for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

First Pass Success Rate

Secondary study objectives

Aspiration rate

Cardiac arrest

Cuff Leak

+8 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: PostinterventionExperimental Treatment1 Intervention

Clinician intubation process after implementation and clinician education with a procedural checklist

Group II: PreinterventionActive Control1 Intervention

Normal clinician intubation process

Do I qualify?Apply below to find out

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Rapid Sequence Intubation (RSI) involves the administration of sedatives and paralytics to facilitate quick and safe endotracheal intubation. Sedatives like etomidate or propofol induce rapid unconsciousness, while paralytics such as succinylcholine or rocuronium cause muscle relaxation, preventing reflexive movements and facilitating easier intubation. Hemodynamic management, including the use of agents like phenylephrine, ensures stable blood pressure during the procedure. Standardization and protocolization of these treatments are critical to minimize complications, ensure consistency, and improve overall patient outcomes during emergency intubations.

A Systematic Review on Surgical Treatments for Sulcus Vocalis and Vocal Fold Scar.Emergency intubation for acutely ill and injured patients.