Motivational Interviewing + Air Cleaners for COPD
(MOVE-COPD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if air cleaners and motivational support can assist smokers with COPD (a lung disease causing breathing difficulties) by improving indoor air quality. Participants will receive either active HEPA air cleaners (devices that filter air) and motivational calls to reduce indoor smoking, or a sham air cleaner and general smoking cessation advice. This trial is ideal for current smokers diagnosed with COPD who experience breathing issues and do not have a smoking ban at home. As an unphased trial, it offers participants a unique opportunity to contribute to research that could enhance their quality of life and aid others with similar conditions.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it does exclude people using chronic systemic corticosteroids. It's best to discuss your specific medications with the trial team.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that active HEPA air cleaners are generally safe for people with COPD (chronic obstructive pulmonary disease). These devices clean the air by removing tiny particles, and studies have not identified any major safety issues. Motivational interviewing, which involves discussions with a counselor to find ways to quit smoking and improve health, is also well-tolerated. People with COPD have found it helpful without experiencing major side effects. Overall, previous research indicates that both treatments are safe.12345
Why are researchers excited about this trial?
Researchers are excited about this trial because it combines motivational interviewing with active HEPA air cleaners to tackle COPD in a new way. Unlike standard treatments that primarily focus on medication to manage symptoms, this approach aims to reduce secondhand smoke exposure at home, which is a key trigger for COPD flare-ups. The use of motivational interviewing is particularly noteworthy because it supports behavioral changes, such as implementing a home smoking ban, which can lead to lasting improvements in air quality and overall lung health. This innovative combination has the potential to enhance the effectiveness of standard care by addressing environmental factors and encouraging healthier lifestyle choices.
What evidence suggests that this trial's treatments could be effective for COPD?
Research has shown that active HEPA air cleaners, provided to participants in the active treatment arm of this trial, can reduce indoor air pollution, improving health for people with COPD. Studies have found that these air cleaners lower the risk of moderate COPD flare-ups and reduce the need for extra medications by decreasing harmful particles in the air.
Additionally, motivational interviewing, also included in the active treatment arm, has improved lung function and reduced hospital visits for COPD patients. This approach builds confidence in managing health and encourages healthier habits like quitting smoking. Together, these treatments aim to improve breathing and overall lung health for people with COPD.14678Who Is on the Research Team?
Nadia N Hansel, MD, MPH
Principal Investigator
Johns Hopkins University
Are You a Good Fit for This Trial?
The MOVE COPD trial is for current smokers over 40 years old with a physician's diagnosis of moderate to severe COPD. Participants must have smoked the equivalent of at least 10 packs of cigarettes per year and not enforce a smoking ban in their homes. They cannot have other chronic lung diseases, live outside their home, plan to move during the study period, or be on long-term systemic corticosteroids.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Run-in
Participants receive smoking cessation strategies including Motivational Interviewing and nicotine replacement therapy
Treatment
Participants receive either active HEPA air cleaners and motivational interviewing or sham air cleaners
Follow-up
Participants are monitored for changes in COPD health status, dyspnea, quality of life, and systemic markers of inflammation
What Are the Treatments Tested in This Trial?
Interventions
- Active HEPA Air Cleaner
- Motivational interviewing
- Sham Air Cleaner
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
National Institute of Environmental Health Sciences (NIEHS)
Collaborator