Motivational Interviewing + Air Cleaners for COPD
(MOVE-COPD Trial)
Trial Summary
What is the purpose of this trial?
COPD is characterized by lung injury and inflammation caused by noxious particles and gases, including those emanating from cigarette smoke and air pollution. Despite the clear detrimental impact of poor air quality on respiratory outcomes, regardless of smoking status, to investigators' knowledge, there are no studied environmental interventions targeting indoor air quality to improve respiratory health of smokers, thus ignoring a potential target for harm reduction. Investigators propose a randomized controlled intervention trial to test whether targeted reductions of multiple indoor pollutants (PM, SHS and NO2) in homes of smokers with COPD will improve respiratory outcomes. Investigators have chosen a potent, multimodal intervention (active air cleaners + Motivational intervention for SHS reduction) in order to maximize the opportunity to prove that there is a health benefit to active smokers with COPD from indoor air pollution reduction.
Research Team
Nadia N Hansel, MD, MPH
Principal Investigator
Johns Hopkins University
Eligibility Criteria
The MOVE COPD trial is for current smokers over 40 years old with a physician's diagnosis of moderate to severe COPD. Participants must have smoked the equivalent of at least 10 packs of cigarettes per year and not enforce a smoking ban in their homes. They cannot have other chronic lung diseases, live outside their home, plan to move during the study period, or be on long-term systemic corticosteroids.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Run-in
Participants receive smoking cessation strategies including Motivational Interviewing and nicotine replacement therapy
Treatment
Participants receive either active HEPA air cleaners and motivational interviewing or sham air cleaners
Follow-up
Participants are monitored for changes in COPD health status, dyspnea, quality of life, and systemic markers of inflammation
Treatment Details
Interventions
- Active HEPA Air Cleaner
- Motivational interviewing
- Sham Air Cleaner
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Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
National Institute of Environmental Health Sciences (NIEHS)
Collaborator