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Radiation Therapy
MRI-Guided Prostate SBRT for Prostate Cancer (ARGOS/CLIMBER Trial)
N/A
Recruiting
Research Sponsored by Lawson Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age > 18 years of age
Histologically confirmed carcinoma of the prostate
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
ARGOS/CLIMBER Trial Summary
This trial is testing a new way to treat prostate cancer that is more precise and has fewer side effects.
Who is the study for?
Men over 18 with high intermediate-risk, high-risk, or very high-risk prostate cancer that hasn't spread beyond the pelvis. They must have no history of prior prostate cancer treatments (except for certain medications), be able to undergo MRI and PSMA PET scans without contraindications like incompatible implants, and not have severe urinary problems or conditions preventing radiotherapy.Check my eligibility
What is being tested?
The trial is testing a targeted radiation therapy called SBRT guided by PSMA PET scans and mpMRI images in men with specific risk levels of prostate cancer. It involves fusing these images with CT simulations for precise tumor targeting, using fiducial markers for motion management during treatment, and escalating doses to identified targets while protecting surrounding organs.See study design
What are the potential side effects?
Potential side effects may include irritation or damage to nearby organs such as the bladder and rectum due to radiation exposure, changes in urinary function, fatigue from treatment sessions, skin reactions at the site of radiation application, and possible allergic reactions to imaging agents used.
ARGOS/CLIMBER Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am older than 18 years.
Select...
My prostate cancer has been confirmed by a tissue examination.
ARGOS/CLIMBER Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
6-month Toxicity
6-week Toxicity
Secondary outcome measures
Disease Free Survival
Quality of Life
ARGOS/CLIMBER Trial Design
1Treatment groups
Experimental Treatment
Group I: Men with high intermediate to very high risk protstate cancerExperimental Treatment2 Interventions
Find a Location
Who is running the clinical trial?
Lawson Health Research InstituteLead Sponsor
659 Previous Clinical Trials
413,682 Total Patients Enrolled
15 Trials studying Prostate Cancer
595 Patients Enrolled for Prostate Cancer
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I cannot undergo intense prostate radiotherapy due to certain health conditions like connective tissue disease.I have had prostate cancer treatment, but not hormone therapy before joining.My cancer has spread beyond the pelvic area.I am older than 18 years.My prostate cancer is classified as high-intermediate, high, or very-high risk.My prostate cancer has been confirmed by a tissue examination.I have a bleeding disorder.I do not have clinical T4 disease.I am allergic or cannot tolerate the PSMA PET agent PSMA 1007.I cannot safely stop my blood thinner medication for a procedure.
Research Study Groups:
This trial has the following groups:- Group 1: Men with high intermediate to very high risk protstate cancer
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How many individuals are partaking in this research initiative?
"Correct. Per the information on clinicaltrials.gov this trial, which was first posted on May 3rd 2022, is actively seeking participants. To date they are aiming to recruit 50 individuals from one medical facility."
Answered by AI
Has recruitment begun for this particular experiment?
"Per information on clinicaltrials.gov, this trial is still open to enrolment and was recently refreshed on May 4th 2022 after being initially advertised on the 3rd of May in the same year."
Answered by AI
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