Biomarker Modeling for Dementia
(CRND TorCA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to create a model to predict the progression of neurodegenerative diseases that cause dementia. It focuses on conditions such as Mild Cognitive Impairment (MCI) and dementia due to Alzheimer's, Lewy Body Disease, Vascular Disease, and Frontotemporal degeneration. Candidates include those diagnosed with MCI or early dementia who have someone seeing them weekly. The goal is to enhance understanding of these diseases and assist doctors in making more informed patient care decisions. As an unphased study, this trial allows patients to contribute to groundbreaking research that could improve future care strategies.
Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to improve the way we predict the progression of neurodegenerative diseases causing dementia, like Alzheimer's and Parkinson's. Unlike current methods that rely heavily on brain imaging and cognitive tests, this trial explores the use of peripheral biomarkers—substances that can be measured in blood or other body fluids—to provide insights. By integrating these biomarkers with advanced modeling techniques, the goal is to offer a more accurate and non-invasive way to track disease progression. This could lead to earlier and more personalized treatment plans, potentially improving patient outcomes significantly.
Who Is on the Research Team?
Maria C Tartaglia, M.D.
Principal Investigator
Toronto Western Hospital, UHN; Tanz CRND
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo baseline assessments including brain imaging, body fluid samples, skin biopsy, cognitive ability, and behavioral questionnaires
Follow-up
Participants are monitored for changes in neurodegenerative protein levels, structural and functional brain differences, and cognitive phenotype
What Are the Treatments Tested in This Trial?
Find a Clinic Near You
Who Is Running the Clinical Trial?
University Health Network, Toronto
Lead Sponsor
Baycrest
Collaborator
Sunnybrook Health Sciences Centre
Collaborator
Centre for Addiction and Mental Health
Collaborator
University of Toronto
Collaborator
Toronto Dementia Research Alliance (TDRA)
Collaborator