Knee Immobilization for Postoperative Pain
(REST-Knee Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Postoperative pain following total knee arthroplasty (TKA) is often difficult to manage, particularly with the increasing use of outpatient surgery where patients recover at home. This study aims to evaluate whether wearing a knee extension brace for the first 72 hours after surgery can reduce pain and improve recovery.
This pilot randomized controlled trial will compare two groups of patients undergoing primary unilateral TKA: one group will wear an extension brace continuously for 72 hours after surgery, while the control group will follow standard care with early mobilization. Participants will be followed for up to 12 months.
The primary objective of this pilot study is to assess the feasibility of conducting a larger trial, including recruitment rates, adherence to the intervention, follow-up completion, safety, and acceptability. Clinical outcomes will also be explored, including pain at 2 and 6 weeks after surgery (measured using a visual analog scale), knee function, range of motion, opioid consumption, complications, healthcare use, and quality of life.
The study hypothesizes that short-term immobilization of the knee in full extension will reduce postoperative pain and may improve early recovery outcomes. Findings from this pilot study will inform the design of a larger definitive trial and may contribute to improving postoperative care and pain management after knee replacement surgery.
Who Is on the Research Team?
Yoan Bourgeault-Gagnon, MD FRCSC
Principal Investigator
Université de Sherbrooke
François Vaillancourt, MD FRCSC
Principal Investigator
Université de Sherbrooke
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo primary unilateral TKA and are randomized to either wear a knee extension brace for 72 hours or follow standard care with early mobilization.
Follow-up
Participants are monitored for pain, knee function, and other clinical outcomes at various intervals post-surgery.
Extension/Long-term follow-up
Participants continue to be monitored for long-term outcomes and safety.
What Are the Treatments Tested in This Trial?
Interventions
- Knee Extension Brace
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will undergo postoperative immobilization of the operated knee in full extension using a Zimmer-type knee brace for 72 hours following primary total knee arthroplasty, followed by standard physiotherapy care.
Participants will receive standard postoperative care consisting of early mobilization without movement restriction and supervised physiotherapy according to usual clinical practice.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Université de Sherbrooke
Lead Sponsor
Unbiased Results
We believe in providing patients with all the options.
Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.
Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.