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60 Participants NeededMy employer runs this trial

Exercise Training for Type 1 Diabetes

(ZQL010 Trial)

ZL
LH
Overseen ByLee Hartline, MEd
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of Virginia
Must be taking: Insulin
Must not be taking: Vasoactive medications, Oral contraceptives
Disqualifiers: Chronic disease, Smoking, Hypertriglyceridemia, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is:

* To see if insulin resistance (how sensitive your muscle tissue is to insulin) is associated with lower cardio fitness in people with Type 1 diabetes compared to healthy controls, before and after a High Intensity Interval Training (HIIT) exercise program.

* To see if being overweight and having Type 1 diabetes is associated with lower cardio fitness compared to overweight healthy controls, before and after a HIIT exercise program.

Who Is on the Research Team?

ZL

Zhenqi Liu, MD

Principal Investigator

University of Virginia

Are You a Good Fit for This Trial?

Inclusion Criteria

Body mass index: 19 to 27 kg/m2 for control and T1D, 30 to 40 kg/m2 (27.5 to 37.5 for Asian Americans) for obesity and T1D + obesity. BMI limited to 40 kg/m2 (37.5 for Asian Americans) for easier vascular access and cardiac imaging
I have been on the same non-insulin meds for over 6 months and stopped hormone pills 3 months ago.
I am between 21 and 50 years old.
See 1 more

Exclusion Criteria

Pregnant (as evidenced by positive pregnancy test) or nursing women
I have taken birth control pills in the past 3 months.
I currently smoke or quit smoking less than 5 years ago.
See 11 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Exercise Training

Participants undergo a High Intensity Interval Training (HIIT) exercise program

15 weeks

Follow-up

Participants are monitored for changes in VO2max and insulin-mediated changes in muscle

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • High Intensity Interval Training

How Is the Trial Designed?

4

Treatment groups

Active Control

Group I: Type 1 diabetes - normal weightActive Control1 Intervention
Group II: Control - normal weightActive Control1 Intervention
Group III: Overweight controlActive Control1 Intervention
Group IV: Type 1 diabetes - overweightActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Virginia

Lead Sponsor

Trials
802
Recruited
1,342,000+

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