BMAC for Osteoarthritis
What You Need to Know Before You Apply
What is the purpose of this trial?
The proposed research study aims to evaluate the effects of autologous bone marrow aspirate concentrate (BMAC) on the development and progression of osteoarthritis (OA) in patients undergoing meniscectomy. This prospective, randomized, double-blind clinical trial will compare patient-reported outcomes, specifically IKDC scores between patients who receive BMAC post-meniscectomy and those who receive a saline control injection. The study will also compare physical examination, MRI, radiographs, and synovial fluid analysis. Our hypothesis is that those who receive the autologous BMAC injection after the procedure will have better outcomes than those who do not.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. However, if you have had a cortisone, viscosupplementation, or PRP injection in the last 6 weeks, you may not be eligible to participate.
Is BMAC safe for treating osteoarthritis?
How is the BMAC treatment different from other treatments for osteoarthritis?
BMAC (Bone Marrow Aspirate Concentrate) is unique because it involves injecting a concentrate derived from a patient's own bone marrow into the affected joint, which provides growth factors with potential anti-inflammatory and tissue-repairing effects. Unlike other treatments, BMAC uses the body's own cells to potentially improve joint function and reduce symptoms.12467
What data supports the effectiveness of the treatment Autologous Bone Marrow Aspirate Concentrate (BMAC) for osteoarthritis?
Who Is on the Research Team?
Brian Cole, MD
Principal Investigator
Midwest Orthopaedics at Rush
Are You a Good Fit for This Trial?
This trial is for adults over 18 with a painful meniscal tear confirmed by MRI and surgery, who need a meniscectomy. They must have mild to moderate osteoarthritis but no history of rheumatoid arthritis, recent infections requiring antibiotics, prior knee surgeries, or injections within the last 6 weeks. Pregnant individuals or those with diabetes, transplant history, decision-making impairments, recent cancer (except basal cell), or severe osteoarthritis are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo meniscectomy followed by either a BMAC injection or a placebo saline injection
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments including IKDC scores, synovial fluid analysis, and radiographic analysis
What Are the Treatments Tested in This Trial?
Interventions
- Autologous Bone Marrow Aspirate Concentrate
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rush University Medical Center
Lead Sponsor