Aspiration Thrombectomy for Cancer

Overseen By Varshana Gurusamy, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: M.D. Anderson Cancer Center

Disqualifiers: Hemodynamic instability, ECMO, CTEPH, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

Duration: 1 week

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this clinical research study is to gather information about the quality of life benefits of cancer patients with intermediate risk PE who underwent thrombectomy. The safety of thrombectomy in this patient population will also be studied.

Who Is on the Research Team?

Varshana Gurusamy, MD

Principal Investigator

M.D. Anderson Cancer Center

Are You a Good Fit for This Trial?

This trial is for cancer patients who have a condition called intermediate risk pulmonary embolism (PE). Specific eligibility criteria are not provided, but typically participants would need to meet certain health standards and not have conditions that could interfere with the study or their safety.

Inclusion Criteria

I have been diagnosed with cancer before.

Confirmed PE based on computed tomographic pulmonary angiography (CTPA) imaging showing a filling defect in at least one main or proximal lobar pulmonary artery

Classification of intermediate risk PE as defined by the institutional PERT algorithm

Exclusion Criteria

Allergy, hypersensitivity, or heparin-induced thrombocytopenia (HIT)

Pregnancy

Patients on ECMO

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo computer-assisted vacuum thrombectomy (CAVT) for intermediate risk pulmonary embolism

1 week

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, including assessments at 48 hours and 90 days post-procedure

12 weeks

Multiple visits (in-person and virtual)

What Are the Treatments Tested in This Trial?

Interventions

• Aspiration Thrombectomy

Trial Overview

The study is examining the use of Computer-assisted Vacuum Thrombectomy (CAVT) in treating PE among cancer patients. It aims to assess both the safety of this procedure and its impact on patients' quality of life after treatment.

How Is the Trial Designed?

Group I: Treatment with Penumbra Element Sheath Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

M.D. Anderson Cancer Center

Lead Sponsor

Trials

3,107

Recruited

1,813,000+