Electrical Impedance Myography for ALS
(ElectricALS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to track the progression of amyotrophic lateral sclerosis (ALS) using Electrical Impedance Myography (EIM). EIM measures muscle health and could help determine how quickly ALS progresses in an individual. The goal is to find a simple, accurate way to monitor ALS from home. Suitable candidates for this trial include those diagnosed with ALS within the last three years who can use the internet for data upload. Participants also need assistance with home visits. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could simplify ALS monitoring for future patients.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial investigators to get a clear answer.
What prior data suggests that Electrical Impedance Myography is safe for tracking ALS progression?
Research has shown that Electrical Impedance Myography (EIM) is a safe and non-invasive method to monitor the progression of ALS, a disease affecting the nerves and muscles. EIM allows doctors to observe disease advancement without invasive procedures, which often have more side effects.
Studies have not reported any serious side effects from EIM, indicating it is generally safe for people with ALS. EIM works by applying small electrical currents to the skin, posing very little risk.
In summary, EIM appears to be a safe way to track ALS progression.12345Why are researchers excited about this trial?
Researchers are excited about using the Myolex mScan as a biomarker for ALS because it offers a new way to monitor disease progression and possibly predict outcomes. Unlike current ALS treatments, which mostly focus on managing symptoms with medications like riluzole or edaravone, this approach aims to provide a clearer picture of how the disease affects muscle health over time. By using electrical impedance myography (EIM), the Myolex mScan could help doctors tailor treatments more effectively and improve patient care.
What evidence suggests that Electrical Impedance Myography is effective for tracking ALS progression?
Research has shown that Electrical Impedance Myography (EIM) is a promising method for tracking the progression of ALS, a disease affecting nerves and muscles. EIM measures how electricity moves through muscles, which changes as ALS progresses. Studies have demonstrated that EIM can effectively monitor muscle health in people with ALS over time. For example, one study observed 15 ALS patients for up to 18 months and found that EIM was useful for assessing disease progression. Additionally, EIM has identified nerve and muscle diseases in animal studies, further supporting its potential. This suggests that EIM could be a helpful, non-invasive, and objective way to track ALS.26789
Who Is on the Research Team?
Masumeh Hatami, MD
Principal Investigator
Beth Israel Deaconess Medical Center
Seward Rutkove, MD
Principal Investigator
Beth Israel Deaconess Medical Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo Electrical Impedance Myography (EIM) assessments to evaluate ALS progression
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Electrical Impedance Myography
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients diagnosed with ALS
Find a Clinic Near You
Who Is Running the Clinical Trial?
Beth Israel Deaconess Medical Center
Lead Sponsor
United States Department of Defense
Collaborator
Citations
Electrical impedance myography to assess outcome in ...
In this paper we report data on 15 ALS patients followed longitudinally for up to 18 months, to determine the potential for EIM as a technique for measuring ...
Study of Electrical Impedance Myography (EIM) in ALS
This trial is studying Electrical Impedance Myography (EIM) for measuring muscle health. The trial is studying people with Amyotrophic Lateral Sclerosis (ALS) ...
Surface electrical impedance myography detects disease ...
In sum, these findings demonstrate that EIM is an effective tool to detect neuromuscular disease in symptomatic adult ALS zebrafish, and the ...
Tensor electrical impedance myography identifies bulbar ...
Electrical impedance myography (EIM) is a promising biomarker for amyotrophic lateral sclerosis (ALS). A key issue is how best to utilise the complex high ...
Tensor electrical impedance myography identifies clinically ...
Electrical impedance myography (EIM) shows promise as an effective biomarker in amyotrophic lateral sclerosis (ALS). EIM applies multiple ...
Electrical impedance myography as a biomarker to assess ...
Electrical impedance myography (EIM), a non-invasive, electrophysiological technique, has preliminarily shown value as an ALS biomarker.
Electrical Impedance Myography as a Biomarker To ...
Conclusions: EIM has the potential of serving as a powerful biomarker in ALS therapeutic trials since it provides a measure for identifying progression over ...
Assessing ALS progression with a dedicated electrical ...
Electrical impedance myography (EIM) has shown promise as biomarker in assessing ALS progression [5]. Unlike standard electrophysiological measures, EIM ...
Neurophysiological and imaging biomarkers of lower motor ...
Estimating Myofiber Size With Electrical Impedance Myography: a Study In Amyotrophic Lateral Sclerosis MICE ... amyotrophic lateral sclerosis: a safety ...
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