Sample Collection for Cancer Research
What You Need to Know Before You Apply
What is the purpose of this trial?
The trial aims to collect tumor and normal tissue samples, along with some blood, to better understand cancer biology and develop new treatments. Individuals scheduled for a biopsy or surgery may be suitable candidates. The process involves collecting tissue samples during the medical procedure, a buccal swab (cheek swab) if needed, and up to 50 mL of blood. Researchers will use these samples to create models for testing potential cancer therapies.
As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could lead to new cancer treatments.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this sample collection is safe?
Research has shown that collecting tissue samples, such as those taken during a biopsy or surgery, is generally safe and well-tolerated. One study found that collecting tissue for research during a breast biopsy is safe and provides valuable information. This process is efficient and poses no significant risks.
For blood collection, taking 50 mL of blood is standard and common in medical research. People typically handle it well, similar to having blood drawn for routine tests. There may be a small risk of bruising or feeling lightheaded, but these effects are minor and temporary.
Overall, existing studies consider the methods used to collect tissue and blood for research safe. Participants can feel assured that these procedures are routinely performed and have a strong safety record.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to create preclinical models using patient-derived tissues, offering a more personalized approach to studying diseases. Unlike standard methods, which often rely on generalized data, this technique uses actual patient samples like tissue, blood, and buccal swabs to better understand how diseases develop and respond to treatments. This approach could lead to more accurate predictions of treatment effectiveness and disease progression, ultimately paving the way for customized therapies tailored to individual patients.
Who Is on the Research Team?
Aaron S. Mansfield, M.D.
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Tissue and Blood Collection
Collection of tumor tissues, matched normal tissue, and approximately 50 mL of blood for research purposes
Preclinical Model Development
Development of preclinical models using collected specimens, including cell lines and patient-derived xenograft models
Follow-up
Participants are monitored for safety and effectiveness after specimen collection
What Are the Treatments Tested in This Trial?
Interventions
- Tissue Collection
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Research tissue specimen will be obtained during the patient's clinical biopsy or clinical tumor resection, if feasible.
Buccal swab may be requested, if necessary, to generate germline data.
Up to 50 mL of research blood will be drawn around the time of the procedure. Additional blood may be collected in selected cases, as warranted, to monitor disease recurrence/remission or perform additional testing
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
Citations
Improving Quality of Cancer Research Biopsy Specimens
Researchers have developed recommendations for improving the quality of biopsy specimens collected from patients participating in cancer clinical trials.
Collection and Storage of Tissue Samples From Patients ...
Tissue is stored for research projects on tumors and treatment of cancer patients. Research may involve analysis of the genetic makeup of the tumor tissue.
The Safety and Suitability of DNA Sequencing of Tissue ...
The safety and suitability of DNA sequencing of tissue biopsies performed on patients referred to a Phase I unit.
The use of research biopsies in oncology trials
The clinical trial protocol must include all relevant biomarker assay requirements including appropriate biopsy specimen collection parameters ...
Systematic tissue collection during clinical breast biopsy is ...
Collection of fresh tissues for research purposes at the time of diagnostic breast biopsy is safe, feasible and efficient, and may provide a high-yield ...
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