Eccentric Resistance Training for Knee Arthritis
(KORRI Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study is testing whether a new type of exercise program, called eccentric overload training using a flywheel device, can improve stair-climbing ability in people with knee osteoarthritis. The flywheel device provides resistance throughout the entire movement and gives extra challenge during the muscle-lengthening phase of exercise. This type of training may improve muscle structure, strength, and coordination more effectively than conventional methods.
The study's central idea is that better muscle quality and improved coordination will lead to smoother, safer stair movement and reduce the risk of falls. Advanced tools such as ultrasound imaging and motion analysis will be used to measure muscle health and movement patterns in detail.
The hypothesis is that individuals with knee osteoarthritis have poorer muscle quality and less coordinated stair-stepping compared to healthy adults, and that performing eccentric overload training will enhance muscle quality, improve movement coordination, and make stair navigation safer and more efficient.
Who Is on the Research Team?
Michael Harris-Love, PT, MPT, DSc, FGSA, FAPTA
Principal Investigator
University of Colorado, Denver
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Initial Exercise
Participants in the initial exercise group undergo an 8-week eccentric overload exercise intervention using a kBox, with two sessions per week.
Detraining
Participants cease the intervention for an 8-week detraining period.
Delayed Exercise
Participants in the delayed exercise group begin the same 8-week kBox training completed by the initial exercise group.
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments including muscle thickness, texture analysis, and stair-stepping smoothness.
What Are the Treatments Tested in This Trial?
Interventions
- Eccentric resistance training
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
The initial exercise group will participate in an 8-week eccentric overload exercise intervention using a kBox, with two sessions per week. Participants will then cease the intervention for 8 weeks to enter a detraining period.
The 'Delayed-Exercise' group will maintain their normal activity, without intervention, for the first 8 weeks of the study. In the second half of the study, they will begin the same 8-week kBox training completed by the 'Initial-Exercise' group.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Colorado, Denver
Lead Sponsor
NIH/NCATS Colorado CTSA Grant Number T32TR004367
Collaborator
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