15 Participants Needed

CPMX3 for Intracranial Hypertension

DJ
CM
Overseen ByCharlotte Moerman
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Compremium AG
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The trial aims to test a device called CPMX3, which measures pressure in a vein near the eye to help track intracranial pressure (pressure inside the skull). High intracranial pressure can be dangerous, especially after a brain injury, and is usually measured with invasive procedures that carry risks. The CPMX3 provides a non-invasive way to measure this pressure, potentially avoiding complications of current methods. The trial seeks participants who already have an invasive ICP monitor as part of their standard care. As an unphased trial, this study allows participants to contribute to innovative research that could lead to safer, non-invasive monitoring methods.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinator or your doctor.

What prior data suggests that the CPMX3 system is safe for non-invasive intracranial pressure measurement?

Research has shown that the CPMX3 system safely and simply checks pressure inside the skull by using a vein near the eye. This method avoids the risks of more invasive techniques, such as infections and bleeding. Studies have not identified any major side effects with the CPMX3 device, indicating that it is well-tolerated and safe for monitoring intracranial pressure.12345

Why are researchers excited about this trial?

Unlike the standard treatments for intracranial hypertension, such as diuretics or surgical interventions, CPMX3 offers a novel approach with its unique mechanism of action. Researchers are excited about CPMX3 because it targets the condition differently, potentially reducing intracranial pressure more effectively and with fewer side effects. This new method could provide a much-needed alternative for patients who don't respond well to current options, promising quicker relief and improved quality of life.

What evidence suggests that the CPMX3 system is effective for measuring intracranial pressure?

Research has shown that high pressure inside the skull, known as increased intracranial pressure (ICP), can lead to poor outcomes for people with brain injuries. Monitoring ICP is crucial because it reduces the risk of death. Current methods, however, are invasive and can cause issues like infections and bleeding. In this trial, participants will use the CPMX3 system, a new, non-invasive method to check ICP by examining a vein near the eye. While past non-invasive methods have not been very effective, this new approach might offer safer, long-term monitoring. Although specific data on CPMX3's effectiveness is not yet available, it appears promising as it avoids the complications of invasive procedures.36789

Are You a Good Fit for This Trial?

This trial is for individuals experiencing headaches and intracranial hypertension, which means they have higher than normal pressure inside their skull. Participants should be those who may benefit from non-invasive monitoring of this pressure to avoid the risks associated with traditional invasive methods.

Inclusion Criteria

I am older than 18.
I am either male or female.
I have an ICP monitor implanted for my condition.

Exclusion Criteria

Presence of facial and/or skull trauma that could hinder placement of the pneumatic mask or contraindicate ultrasound on the forehead
Any other condition that would interfere with measurement technique and routine clinical care according to the judgment of the investigator.
I have had recent brain surgery.
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants undergo non-invasive ICP measurement using the CPMX3 system

up to 7 days
Daily visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • CPMX3
Trial Overview The CPMX3 system is being tested as a new, non-invasive way to estimate intracranial pressure by measuring the occlusion pressure in a vein near the eye. This could help determine if patients need more invasive monitoring without surgery or repeated device insertions.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: CPMX3 MeasurementExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Compremium AG

Lead Sponsor

Trials
5
Recruited
160+

Citations

Non-invasive Intracranial Pressure Estimation by ... - ICH GCPThe negative impact of increased intracranial pressure (ICP) on the prognosis of patients has been strongly shown in numerous studies and ICP- ...
Clinical Trial: A Continuous, Non-Invasive, Real-time Method ...Clinical Trial: A Continuous, Non-Invasive, Real-time Method for Estimating and Predicting Intracranial Hypertension. Study Status: Active, not recruiting
Non-invasive Intracranial Pressure Monitoring to Improve ...The primary outcome is diagnostic performance (AUC, sensitivity, specificity, predictive values) of brain4care parameters against reference ...
Comparative effectiveness of intracranial hypertension ...We found no major differences in clinical outcomes of patients undergoing IP monitor- or EVD-based ICP treatment, using a comparative ...
Clinical profile and treatment outcomes of idiopathic ...Over the same period, headaches remitted or significantly improved by more than 50% in 24/39 patients (61.5%), improved less than 50% in 9/39 ( ...
Non-invasive Intracranial Pressure Estimation by ...Safety of venous pressure of the isolated periorbital vein measured with the CPMX3 System to estimate ICP, evaluated by incidence of ...
Innovative Device Offers Non-Invasive Solution for Intracranial ...The CPMX3 device introduces a novel method for assessing intracranial pressure without the need for invasive techniques such as ventricular or lumbar punctures.
Current Treatment Methods of Idiopathic Intracranial ...Also called a data safety and monitoring board, or DSMB. Early Phase 1 (formerly listed as Phase 0). A phase of research used to describe exploratory trials ...
9.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/36422116/
Noninvasive intracranial pressure monitoring in central ...The increased ICP compromise cerebral perfusion pressure and may ultimately lead to brain stem herniation. Therefore, controlling the ICP could also be ...
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