LYPS Intervention for HIV Prevention
(LYPS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The LYPS intervention is a multi-level intervention that combines: a) structural-level delivery of PrEP and PrEP services by a community health professional (CHP) at a designated place in the community being offered by the SC where PrEP is not yet provided (e.g., participant's home, community partner location, or traveling mobile van), with b) an individual-level mobile application (app) to support PrEP adherence and persistence between CHP visits.
Who Is on the Research Team?
Keith Horvath
Principal Investigator
San Diego State University
Audrey Pettifor
Principal Investigator
UNC Chapel Hill
Lisa Hightow-Weidman, MD, MPH
Principal Investigator
Florida State University
Sybil Hosek, PhD
Principal Investigator
University of Illinois at Chicago
Kate Muessig
Principal Investigator
Florida State University
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Enrollment
Participants are enrolled and randomized into either the LYPS intervention or enhanced standard of care (eSOC) control condition
Treatment
Participants receive PrEP and PrEP care through community delivery or clinic-based care, supplemented by a mobile app for adherence support
Follow-up
Participants are monitored for PrEP adherence and persistence, including blood collection and self-interviews
What Are the Treatments Tested in This Trial?
Interventions
- LYPS
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
PrEP and PrEP care will be delivered to youth in the communities where they live through a Community Health Professional (CHP) (e.g., a nurse or other qualified health care professional home, friend's home, community venue or clinic, mobile health clinic), supplemented by a mobile app to provide real-time intervention between CHP visits.
Usual standard of care clinic-based PrEP, enhanced with access to a limited number of LYPS app components, including basic PrEP adherence information and study visit reminders.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Westat
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
National Institute of Mental Health (NIMH)
Collaborator
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator
National Institutes of Health (NIH)
Collaborator
The Emmes Company, LLC
Industry Sponsor
Peter Ronco
The Emmes Company, LLC
Chief Executive Officer since 2023
BSc from Nottingham University
Dr. Joe Sliman
The Emmes Company, LLC
Chief Medical Officer since 2020
MD from Uniformed Services University of the Health Sciences, MPH from Johns Hopkins University, BSc in Molecular and Cell Biology from Pennsylvania State University
Florida State University
Collaborator
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