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PEEP for Cardiac Surgery Patients

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Overseen ByVahid Kiarad, MD, MPH
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Beth Israel Deaconess Medical Center
Disqualifiers: Arrhythmia, Valvular disease, Lung disease, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this single-center, prospective study is to evaluate the physiologic effect of changes in PEEP on biventricular mechanics and RV-pulmonary arterial (RV-PA) coupling in adult patients undergoing cardiac surgery.

Are You a Good Fit for This Trial?

Inclusion Criteria

I am 18 years old or older.
I am scheduled for heart surgery with general anesthesia.
I am scheduled to have a TEE during my surgery as part of my routine care.
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Exclusion Criteria

Severe valvular disease where protocol-related PEEP changes may pose unacceptable hemodynamic risk, as determined by the clinical team
Significant chronic lung disease or other pulmonary pathology where PEEP adjustments may be unsafe (e.g., severe COPD with dynamic hyperinflation, bullous lung disease), at the discretion of the anesthesia team
I cannot safely have changes made to my breathing machine settings.
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Perioperative Assessment

Evaluation of biventricular mechanics and RV-PA coupling using PEEP titration sequence

20-25 minutes
1 visit (in-person, during surgery)

Follow-up

Participants are monitored for safety and effectiveness after the perioperative assessment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • EIT Guided PEEP Trial

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: Optimized PEEP GroupExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Beth Israel Deaconess Medical Center

Lead Sponsor

Trials
872
Recruited
12,930,000+

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