Dihydroberberine for Healthy Adults
(DHB Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this clinical trial is to evaluate whether dihydroberberine (DHB) supplementation can improve body composition, blood sugar control, energy levels, appetite, and mood in healthy adults with overweight or mild obesity. The study focuses on men and women aged 35-55 years with a BMI between 27.0 and 33.0 kg/m².
The main questions it aims to answer are:
Does daily DHB supplementation lead to greater reductions in body weight over 12 weeks compared to placebo? Does DHB improve glycemic responses, appetite regulation, energy levels, and mood, both acutely (short-term) and chronically (over 12 weeks)?
Researchers will compare two groups-one receiving DHB (400 mg/day) and the other receiving a placebo-administered as two capsules twice daily for 12 weeks. Participants will:
Attend three in-clinic visits over approximately 14 weeks (including screening, baseline, and week 12 visits) Undergo mixed-meal tolerance tests (MTTs) to assess glucose metabolism, appetite, and energy levels Complete body composition assessments (including DXA scans), blood tests (e.g., glucose, insulin, HbA1c), and mood questionnaires (POMS-2) Be monitored for safety throughout the study
Are You a Good Fit for This Trial?
This trial is for healthy adults aged 35-55 with a BMI of 27.0 to 33.0, who don't use tobacco or marijuana regularly and are willing to follow study procedures and use a smartphone app. They must have good vein access for blood draws.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive DHB or placebo for 12 weeks, with assessments including MTTs, body composition, and mood questionnaires
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Dihydroberberine
Trial Overview
The trial tests if dihydroberberine (DHB) can improve body composition, blood sugar control, energy levels, appetite, and mood in overweight individuals compared to a placebo over 12 weeks.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Find a Clinic Near You
Who Is Running the Clinical Trial?
Nanjing Nutrabuilding Bio-tech Co., Ltd.
Lead Sponsor
Biofortis, Merieux NutriSciences
Industry Sponsor
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