UVA-1 Therapy for Sclerosing Skin Diseases
Trial Summary
What is the purpose of this trial?
The purpose of this study is to assess the degree of improvement seen patient reported outcomes after 30 sessions of UVA-1 therapy in treating systemic scleroderma, morphea, and sclerodermatous Graft-Versus-Host Disease. While patients have verbally reported improvement of their sclerosing skin disease with UVA-1, patient reported outcomes have not been rigorously studied. In sclerosing skin diseases where clinical change is difficult to measure, patient reported outcomes may offer a better way to study the impact of treatments like UVA-1. This will be a non-blinded, non-randomized prospective trial using UVA-1 phototherapy in patients with established sclerosing skin disease. Patients will report the severity of their condition using multiple patient reported outcomes and will also be analyzed using multiple clinical investigator assessments at the beginning and end of 30 treatment sessions.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
What data supports the effectiveness of the treatment UVA-1 Therapy for sclerosing skin diseases?
Research shows that UVA-1 therapy is effective for treating sclerotic skin diseases, including localized scleroderma and systemic sclerosis, with improvements in skin hardness and lesions. Studies have demonstrated significant skin improvement in patients, indicating its effectiveness for these conditions.12345
Is UVA-1 therapy safe for humans?
How is UVA-1 therapy different from other treatments for sclerosing skin diseases?
UVA-1 therapy is unique because it uses a specific range of ultraviolet light (340-400 nm) to treat sclerosing skin diseases, which can help reduce skin hardening by affecting collagen deposition. Unlike some other treatments, it is non-invasive and has been shown to be effective for conditions that are often resistant to standard therapies.127910
Research Team
Christopher B. Hansen, M.D.
Principal Investigator
University of Utah MidValley Dermatology
Eligibility Criteria
This trial is for adults over 18 with sclerosing skin diseases like systemic scleroderma, morphea, or Graft-Versus-Host Disease affecting the skin. Participants must be able to complete 30 UVA-1 therapy sessions within 100 days and provide consent. Pregnant individuals, those intolerant to UV light, or who have used UV therapy/tanning beds in the last month cannot join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo 30 sessions of UVA-1 phototherapy to treat sclerosing skin diseases
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- UVA-1 Therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Utah
Lead Sponsor