Advanced MRI for Brain Tumor
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether repeated MRI scans (Magnetic Resonance Imaging) can help doctors better understand how a brain tumor, specifically a high-grade glioma, responds to radiation and chemotherapy. By closely monitoring changes in the tumor, the treatment plan, which includes Personalized Adaptive Radiotherapy, may be adjusted to better suit each patient's needs. The trial seeks participants diagnosed with high-grade glioma who can undergo MRI scans with a contrast dye.
As a Phase 2 trial, this research measures how well the treatment works in an initial, smaller group of people, offering participants a chance to contribute to advancements in personalized cancer care.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that repeated MRI scans are safe for patients with high grade glioma?
Research has shown that personalized adaptive radiotherapy is generally safe for patients. One study found that MRI-guided radiotherapy carries a low risk of serious side effects, indicating that patients usually tolerate the treatment well. Another study highlighted the emphasis on safety when using adaptive radiation techniques. These findings suggest that patients can undergo personalized adaptive radiotherapy with a low chance of serious adverse effects.12345
Why are researchers excited about this trial?
Researchers are excited about the use of personalized adaptive radiotherapy for high-grade glioma because it tailors treatment to each patient's unique tumor characteristics. Unlike traditional radiotherapy, this method uses advanced MRI scans to guide and adjust treatment in real-time, potentially improving precision and effectiveness. This adaptive approach could enhance outcomes by targeting cancer cells more accurately while sparing healthy tissue, offering hope for better control of this aggressive brain cancer.
What evidence suggests that repeated MRI scans are effective for identifying changes in high grade glioma during treatment?
Research has shown that personalized adaptive radiotherapy (ART), under study in this trial, can lead to better outcomes for cancer patients. ART adjusts to changes in the body, enhancing precision and reducing side effects. Past studies demonstrated that ART improved the quality of treatment plans, earning high praise from doctors. Some patients reported better experiences, requiring fewer radiation sessions. Overall, ART promises personalized care that adapts to tumor changes during treatment.56789
Who Is on the Research Team?
Caroline Chung
Principal Investigator
M.D. Anderson Cancer Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Patients undergo MRI with and without contrast immediately before radiotherapy for radiation planning and at mid-treatment (week 3). Additional MRIs without contrast are conducted on weeks 1, 2, 4, 5, and 6 of radiotherapy.
Chemotherapy
Concurrent chemotherapy is administered alongside radiotherapy, with adjustments based on MRI findings.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including neurocognitive function testing at 3 and 6 months post-treatment.
What Are the Treatments Tested in This Trial?
Interventions
- Magnetic Resonance Imaging
- Personalized Adaptive Radiotherapy
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients undergo MRI with and without contrast immediately before radiotherapy (for radiation planning) and at mid treatment (week 3). Patients also undergo MRI without contrast on weeks 1, 2, 4, 5, and 6 of radiotherapy. Patients may also undergo neurocognitive function testing over 70 minutes before treatment, at the end of each week of treatment, and at 3 and 6 months after completion of treatment.
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
Citations
Adaptive Radiotherapy: Next-Generation ... - PubMed Central
ART offers more precise cancer treatment by adapting to changes in the patient's body, leading to better outcomes with fewer side effects.
Cost-effectiveness of personalized policies for ...
The purpose of this study was to develop a decision-making model for implementation of personalized ART that balances the costs and clinical benefits of ...
Quantum-enhanced intelligent system for personalized ...
Medical physicists rated the system's efficiency at 4.7/5.0, while radiation oncologists gave treatment plan quality scores of 4.6/5.01. The ...
Patient-Reported Outcomes-Guided Adaptive Radiation ...
Purpose: To identify which patient-reported outcomes (PROs) may be most improved through adaptive radiation therapy (ART) with the goal of reducing toxicity ...
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ama-assn.org
ama-assn.org/practice-management/digital-health/use-ai-advances-adaptive-radiotherapy-cancer-careUse of AI advances adaptive radiotherapy for cancer care
The improved efficiency has lowered treatment time for patients—and has sometimes even resulted in fewer radiation treatments. For patients who ...
A phase II study of personalized ultrafractionated stereotactic ...
Personalized ultrafractionated stereotactic adaptive radiotherapy (PULSAR) is a novel radiotherapy ... safety data are available will be included in the safety ...
Quality and Safety Considerations for Adaptive Radiation ...
Quality and Safety Considerations for Adaptive ... Utilising pseudo-CT data for dose calculation and plan optimization in adaptive radiotherapy.
Safety and Tolerability of Online Adaptive High-Field ...
The findings of this study suggest that online adaptive MR-guided radiotherapy is associated with a low risk of high-grade acute toxic effects.
Personalized Ultra-fractionated Stereotactic Adaptive ...
Also called a data safety and monitoring board, or DSMB. Early Phase 1 (formerly listed as Phase 0). A phase of research used to describe exploratory trials ...
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