Telehealth Exercise for Post-Transplant Frailty

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: City of Hope Medical Center

Disqualifiers: Cardiovascular disease, Exercise contraindications, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 24

Duration: 8 weeks

21 Participants Needed

Trial Summary

What is the purpose of this trial?

This clinical trial studies the feasibility of implementing a telehealth exercise platform to reduce frailty in patients after bone marrow transplant. The exercise program uses a telehealth platform (e.g. smart phones, tablets or computers) to view pre-recorded exercise videos on coordination, posture, stretching, balance and resistance/aerobic training. Physical activity may help to improve physical function, including frailty, after bone marrow transplant. Information from this trial may help researchers design future telehealth exercise routines for treating people with cancer.

Research Team

Kyuwan Lee

Principal Investigator

City of Hope Medical Center

Eligibility Criteria

This trial is for adults over 18 who are at least two years post-bone marrow transplant, in remission, and identified as pre-frail or frail. They must be able to consent, perform study procedures, speak English, and have internet plus a smartphone. Excluded are those with exercise contraindications like acute infections or physical disabilities, regular exercisers (>60 mins/week), those with serious heart conditions, or women who are pregnant/planning pregnancy.

Inclusion Criteria

English speaking

You have a condition called pre-frailty or frailty, identified by a questionnaire called the Bone Marrow Transplant Survivorship Study (BMTSS). This means you may have symptoms like being underweight, feeling exhausted, having low energy, walking slowly, and having weak muscles. If you have at least three out of five of these symptoms, you are considered frail, and if you have two out of five, you are considered pre-frail.

Has access to the internet and a smartphone

Exclusion Criteria

I have a history of serious heart problems.

I am pregnant or planning to become pregnant.

You need to exercise for more than 60 minutes every week.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants in Arm A participate in telehealth exercise sessions at home over 30 minutes with a trainer 3 days a week for 8 weeks. Arm B participants maintain normal activities for 8 weeks before starting the exercise program.

8 weeks

24 sessions (virtual)

Follow-up

Participants are monitored for changes in physical functioning, including chair stand, gait speed, and timed balance.

1 week

Treatment Details

Interventions

• Exercise Intervention

Trial Overview The trial tests a telehealth exercise program aimed at reducing frailty after bone marrow transplant. Participants will use devices like smartphones to follow online videos covering exercises such as coordination and balance training. The goal is to improve physical function and design future telehealth routines for cancer patients.

Participant Groups

Group I: Arm A (telehealth intervention) Experimental Treatment 3 Interventions

Patients participate in telehealth exercise sessions at home over 30 minutes with a trainer 3 days a week for 8 weeks (24 total sessions).

Group II: Arm B (delayed exercise intervention) Active Control 3 Interventions

Patients maintain their normal activities of daily living for 8 weeks before participating in the telehealth exercise program as described in Arm I.

Who Is Running the Clinical Trial?

City of Hope Medical Center

Lead Sponsor

Trials

614

Recruited

1,924,000+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+