Hypofractionated Radiation Therapy for Endometrial Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
Studying adjuvant hypofractionated whole pelvis radiation therapy in Endometrial Cancer.
Do I need to stop my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial team or your doctor.
Is hypofractionated whole pelvis radiation therapy safe for humans?
Research on hypofractionated whole pelvis radiation therapy, particularly in prostate cancer, suggests that it generally has low levels of side effects when compared to traditional radiation therapy. However, it is still considered investigational, and more studies are needed to fully understand its safety profile.12345
How is hypofractionated radiation therapy different for endometrial cancer treatment?
Hypofractionated radiation therapy for endometrial cancer involves delivering higher doses of radiation in fewer sessions compared to traditional radiation therapy, potentially reducing the overall treatment time while maintaining effectiveness. This approach is being explored for its ability to spare healthy tissues and reduce side effects, similar to its use in other cancers like prostate and breast cancer.24678
What data supports the effectiveness of the treatment Hypofractionated Whole Pelvis Radiation Therapy for Endometrial Cancer?
Research on hypofractionated radiation therapy in prostate cancer suggests that it can be effective and well-tolerated, with potential benefits in shortening treatment time and maintaining low side effects. Although specific data for endometrial cancer is limited, similar techniques in prostate cancer show promise for improving outcomes with manageable side effects.12457
Who Is on the Research Team?
Teresa Meier, MD
Principal Investigator
University of Cincinnati
Are You a Good Fit for This Trial?
This trial is for adults over 18 with stage I, II, or III endometrial cancer who've had a hysterectomy and possibly lymph node removal. It's suitable for those needing pelvic radiation but not vaginal cuff brachytherapy due to anatomy or higher risk of nodal recurrence. Participants must be in good general health (ECOG ≤2) and able to consent.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Participants receive hypofractionated whole pelvis radiation therapy to determine the maximum tolerated dose per fraction
Follow-up
Participants are monitored for safety and effectiveness after radiation therapy, focusing on acute gastrointestinal and genitourinary toxicity
What Are the Treatments Tested in This Trial?
Interventions
- Hypofractionated WPRT
Find a Clinic Near You
Who Is Running the Clinical Trial?
Teresa Meier
Lead Sponsor