EEG Monitoring for Anesthetic Depth in Children
What You Need to Know Before You Apply
What is the purpose of this trial?
The goal of this study is monitor anesthetic depth of children undergoing propofol anesthesia using electroencephalography (EEG). The main questions it aims to answer are:1. EEG spectral edge frequency (SEF95) readings where 50% of patients do not respond to three stimuli.2. The propofol blood concentration that corresponds to each of the three EEG SEF95 readings Participants will undergo EEG monitoring, stimuli (placement of oral pacifier, electrical stimulation, and laryngoscopy), and blood collection.
Who Is on the Research Team?
Ian Yuan, MD
Principal Investigator
Children's Hospital of Philadelphia
Are You a Good Fit for This Trial?
This trial is for children aged 3 to 24 months who need surgery with planned laryngoscopy and propofol anesthesia. They should be generally healthy (ASA < III) without muscle relaxants needed for intubation, not on anti-seizure meds, no known difficult airway or severe neurological issues affecting EEG readings, no allergy to propofol, and have a surgery duration less than approximately 2 hours and 40 minutes.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo EEG monitoring and stimuli application to assess anesthetic depth during propofol anesthesia
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- EEG to Monitor Propofol Anesthetic Depth
- Stimuli
Find a Clinic Near You
Who Is Running the Clinical Trial?
Children's Hospital of Philadelphia
Lead Sponsor