Topical CBD for Skin Health

(cannabidiol Trial)

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Penn State University

Disqualifiers: Abnormal heart rate, Diabetes, Nicotine, others

Approved in 3 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 1

Duration: 1 day

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if CBD cream can improve skin health by reducing reactions to certain stimulations. Researchers seek to understand whether CBD, commonly used for pain and wellness, offers real benefits for skin responses in healthy individuals. Participants will receive either a CBD cream or a placebo (a cream without CBD) to compare results. Ideal candidates for this study are healthy, non-nicotine users who have not recently used CBD. As an unphased trial, this study allows participants to contribute to groundbreaking research on CBD's potential benefits for skin health.

Will I have to stop taking my current medications?

The trial information does not specify if you need to stop taking your current medications. However, if you have used CBD in the last 30 days, you cannot participate.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that applying CBD (cannabidiol) creams or lotions to the skin is generally safe and well-tolerated by most people. Studies indicate that CBD can reduce inflammation and relieve pain, benefiting skin health. Notably, CBD typically does not cause common skin allergies, making it a safer option for many. However, most CBD products, including topical ones, lack FDA approval. This means they have not undergone the same rigorous testing for safety and effectiveness as approved medicines. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about using topical CBD for skin health because it offers a natural alternative to traditional treatments like corticosteroids and antibiotics. Unlike these conventional options, cannabidiol works by interacting with the endocannabinoid system, potentially reducing inflammation and soothing the skin without the harsh side effects often associated with steroids. Additionally, CBD's antioxidant properties might help protect the skin from environmental damage, giving it an edge over many current therapies.

What evidence suggests that this trial's treatments could be effective for skin health?

Research shows that applying CBD to the skin might help with inflammation, itching, and pain. It may also support wound healing and be effective for conditions like eczema and psoriasis. Animal studies suggest that CBD could reduce pain and swelling from arthritis when applied topically. Additionally, special forms of CBD that penetrate the skin better have shown improved results in reducing inflammation and aiding wound healing. This trial will compare a topical CBD formulation with a placebo to evaluate its effectiveness for skin health. These findings suggest potential benefits of CBD for skin health, but more human research is needed. ^{1 4 6 7 8}

Are You a Good Fit for This Trial?

This trial is for English-speaking men and women aged 18 or older with a BMI ≤ 39.9 and normal blood sugar levels (HbA1C <6.5%). It's not suitable for those with diabetes, drug use, pregnant/breastfeeding women, abnormal heart rates/BP, skin conditions/allergies, nicotine users, or recent CBD users.

Inclusion Criteria

English speaking

Normal HbA1C of <6.5%

My BMI is 39.9 or less.

Exclusion Criteria

Abnormal resting heart rate (<60 or >100 bpm) or BP (systolic <100 or >129 mmHg, diastolic <60 or >100 mmHg) values

Known skin allergies

I have diabetes.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants receive topical application of CBD or placebo and undergo iontophoresis to assess vascular reactivity

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

1 week

What Are the Treatments Tested in This Trial?

Interventions

• Cannabidiol

Trial Overview

The study tests the effect of topical Cannabidiol (CBD) on skin vascular reactivity using iontophoresis in healthy adults. The goal is to see if CBD can reduce the increased blood flow response that happens when the skin is stimulated.

How Is the Trial Designed?

Group I: Cannabidiol Experimental Treatment 1 Intervention

Active ingredient experimental arm, contains full spectrum connabidiol

Group II: Placebo Placebo Group 1 Intervention

Vehicle control, does not contain cannabidiol

Who Is Running the Clinical Trial?

Penn State University

Lead Sponsor

Trials

380

Recruited

131,000+

Citations

1.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC7736837/

Therapeutic Potential of Cannabidiol (CBD) for Skin Health ...

Though a body of preclinical evidence suggests topical application of CBD may be efficacious for some skin disorders, such as eczema, psoriasis, ...

2.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC9210160/

Topical cannabidiol (CBD) in skin pathology - PubMed Central

Topical cannabis has anti-inflammatory, anti-itching, analgesics, wound healing and anti-proliferative effects on the skin.

3.

sciencedirect.com

sciencedirect.com/science/article/pii/S0939641125001614

Review article Nanoformulated cannabidiol for skin disorders

Cannabidiol (CBD) nanoformulations enhance skin penetration and bioavailability. Nano-CBD platforms show improved anti-inflammatory and wound healing effects.

4.

health.harvard.edu

health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-201808242496

Cannabidiol (CBD): What we know and what we don't

One animal study from the European Journal of Pain suggests CBD could help lower pain and inflammation due to arthritis when applied to skin.

5.

mdpi.com

mdpi.com/2218-273X/15/9/1219

Cannabidiol in Skin Health: A Comprehensive Review of ...

The results demonstrate that CBD exhibits potent activity against biofilms, has a low likelihood of inducing resistance, and shows effectiveness in topical in ...

6.

jidonline.org

jidonline.org/article/S0022-202X(18)31300-9/fulltext

1061 The safety of topical cannabidiol (CBD) for ...

Preliminary results show that 5% BTX 1503 is safe and well tolerated and activity in acne has been observed. This is the first study to evaluate a novel use of ...

7.

jcadonline.com

jcadonline.com/safety-and-sourcing-topical-cannabinoids/

Safety and Sourcing of Topical Cannabinoids

Cannabinoids do not appear to be highly allergenic or common contact allergens thus far and might actually be helpful in attenuating allergic contact dermatitis ...

8.

clinicaltrials.gov

clinicaltrials.gov/study/NCT05456113

Topical Cannabidiol Application and Skin Vascular Reactivity

A phase of research to describe clinical trials that focus on the safety of a drug. They are usually conducted with healthy volunteers, and the goal is to ...