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Learning Health System Intervention for Substance Use Disorders (ADAPT Trial)

Waitlist Available
Research Sponsored by Indiana University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 11 to 22 years old
Be younger than 65 years old
Screening 3 weeks
Treatment Varies
Follow Up 10 years
Awards & highlights


This trial seeks to address the national addiction crisis at its epicenter by creating alliances between the juvenile justice system and community mental health centers to disseminate addiction prevention and treatment.

Who is the study for?
The ADAPT trial is for youth aged 11-22 involved in the juvenile justice system within certain Indiana counties. Participants must have used local community mental health center services during a specific 24-month period.Check my eligibility
What is being tested?
ADAPT aims to create alliances between juvenile justice agencies and community mental health centers using a Learning Health System approach. It will use data to develop localized solutions for substance use disorder care among these youths.See study design
What are the potential side effects?
Since this trial focuses on creating collaborative systems rather than testing medications, it does not involve medical side effects. However, there may be indirect impacts related to changes in service delivery or access.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I am between 11 and 22 years old.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Substance use related health outcomes
Utilization of substance use treatment services

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Learning Health SystemExperimental Treatment1 Intervention
Participating counties receive a system-level intervention, a Learning Health System, designed to improve youth connection to substance use treatment.
Group II: Probation Referral Practice as UsualActive Control1 Intervention
Data are collected regarding standard probation practice and outcomes before implementation of the Learning Health System.

Find a Location

Who is running the clinical trial?

Indiana UniversityLead Sponsor
997 Previous Clinical Trials
1,083,194 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,503 Previous Clinical Trials
2,613,183 Total Patients Enrolled
153 Trials studying Substance Abuse
706,778 Patients Enrolled for Substance Abuse

Media Library

Learning Health System Clinical Trial Eligibility Overview. Trial Name: NCT04499079 — N/A
Substance Abuse Research Study Groups: Probation Referral Practice as Usual, Learning Health System
Substance Abuse Clinical Trial 2023: Learning Health System Highlights & Side Effects. Trial Name: NCT04499079 — N/A
Learning Health System 2023 Treatment Timeline for Medical Study. Trial Name: NCT04499079 — N/A
~1924 spots leftby Apr 2025