20 Participants Needed

Deprescribing Program for Dementia and Diabetes

CS
Overseen ByChristine Slyne
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Joslin Diabetes Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications. However, it focuses on reducing certain diabetes medications that have a high risk of causing low blood sugar. It's best to discuss with the trial team or your doctor.

What data supports the effectiveness of the treatment STRIDE for dementia and diabetes?

Research suggests that reducing unnecessary medications in people with dementia and diabetes can improve their quality of life and reduce hospital readmissions. Comprehensive medication reviews by pharmacists have been shown to help achieve these outcomes.12345

Is the deprescribing program for dementia and diabetes safe for humans?

Research shows that older people with dementia are at risk of adverse events from inappropriate prescribing, and there are adverse drug events in older patients with dementia. However, specific safety data for the deprescribing program itself is not provided in the available research.16789

How is the STRIDE treatment different from other treatments for dementia and diabetes?

The STRIDE treatment is unique because it focuses on deprescribing, which means reducing or stopping medications that may be unnecessary or harmful, especially for older adults with dementia who often take multiple medications. This approach aims to decrease the risk of adverse outcomes by minimizing the burden of unnecessary medication use.310111213

What is the purpose of this trial?

Objectives To 1) examine the ability of the STRIDE (Simplification of Treatment Regimens and Individualized Diabetes Education) educational program to increase deprescribing of high hypoglycemia risk glucose-lowering medications (HRMs) among long term care facility (LTCF) residents with ADRD, 2) assess key implementation constructs (secondary outcomes) of the STRIDE program, including acceptability, appropriateness, and feasibility, and 3) validate the primary HRM use outcome measure.

Research Team

MM

Medha Munshi, MD

Principal Investigator

Joslin Diabetes Center

Eligibility Criteria

This trial is for clinical staff at long-term care facilities, including doctors, physician assistants, nurse practitioners, and clinical pharmacists. They must have participated in the STRIDE program aimed at educating on deprescribing diabetes medication for residents with Alzheimer's.

Inclusion Criteria

This criterion is not related to a clinical trial exclusion criteria. It appears to be related to the targeted providers for a specific program. If you need help with clinical trial exclusion criteria, please provide additional information.
Staff who took part in the STRIDE program (Providers doing stakeholder exit interviews).

Exclusion Criteria

Consistent with the pragmatic nature of the trial, there are no exclusion criteria.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Implementation of the STRIDE educational program to increase deprescribing of high hypoglycemia risk glucose-lowering medications among LTCF residents with ADRD

6 months

Follow-up

Participants are monitored for changes in HRM use and assessed for acceptability, appropriateness, and feasibility of the STRIDE program

6 months

Treatment Details

Interventions

  • STRIDE
Trial Overview The STRIDE educational program is being tested to see if it helps reduce the use of diabetes medications that carry a high risk of causing low blood sugar in elderly patients with dementia. The study will also evaluate how well the program is accepted and implemented by healthcare providers.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: STRIDE InterventionExperimental Treatment1 Intervention
Educational intervention for clinicians

Find a Clinic Near You

Who Is Running the Clinical Trial?

Joslin Diabetes Center

Lead Sponsor

Trials
98
Recruited
26,500+

Brown University

Collaborator

Trials
480
Recruited
724,000+

Theoria Medical

Collaborator

Trials
2
Recruited
320+

Findings from Research

A scoping review identified 12 studies that evaluated various tools for deprescribing medications in people with severe dementia, highlighting the complexity of this task and its potential to improve patient safety and quality of life.
Despite the development of several deprescribing tools, only one study showed a clear clinical benefit from medication withdrawal, indicating a need for more evidence-based research to assess the effectiveness of these tools in clinical practice.
Tools for deprescribing in severe dementia: A scoping review.Wang, C., Roberts, E., Smith, G., et al.[2023]
A systematic review of 26 studies found that the prevalence of potentially inappropriate prescribing in older people with dementia ranges from 14% to 74%, highlighting a significant risk for adverse events in this population.
The Beers criteria were the most commonly used tool for identifying inappropriate prescriptions, but many studies did not utilize the full criteria, suggesting a need for more standardized and comprehensive application of these tools.
Identifying potentially inappropriate prescribing in older people with dementia: a systematic review.Hukins, D., Macleod, U., Boland, JW.[2022]
In a study of 46,737 Medicare beneficiaries and 29,496 Danish participants, cholinesterase inhibitors like donepezil showed similar cardiovascular safety profiles, with no significant differences in the risk of myocardial infarction (MI) or heart failure compared to other medications.
Memantine was linked to a higher risk of fatal or nonfatal MI and cardiac death in the Danish cohort, as well as increased all-cause mortality in both cohorts, suggesting that patients prescribed memantine may have been sicker overall.
Comparative cardiovascular safety of dementia medications: a cross-national study.Fosbøl, EL., Peterson, ED., Holm, E., et al.[2018]

References

Changes in Medication Use After Dementia Diagnosis in an Observational Cohort of Individuals with Diabetes Mellitus. [2021]
Associations of coprescribed medications for chronic comorbid conditions in very old adults with clinical dementia: a retrospective cohort study using insurance claims data. [2021]
Deintensification of Diabetes Medications among Veterans at the End of Life in VA Nursing Homes. [2022]
Pharmacist participation in hospital ward teams and hospital readmission rates among people with dementia: a randomized controlled trial. [2022]
Tools for deprescribing in severe dementia: A scoping review. [2023]
Identifying potentially inappropriate prescribing in older people with dementia: a systematic review. [2022]
Comparative cardiovascular safety of dementia medications: a cross-national study. [2018]
[Adverse events causing discontinuation of donepezil for Alzheimer's dementia]. [2018]
Prevalence of adverse drug events and adverse drug reactions in hospital among older patients with dementia: A systematic review. [2021]
10.United Statespubmed.ncbi.nlm.nih.gov
Ethical Aspects of Physician Decision-Making for Deprescribing Among Older Adults With Dementia. [2023]
The value of deprescribing in older adults with dementia: a narrative review. [2021]
12.United Statespubmed.ncbi.nlm.nih.gov
Deprescribing Education vs Usual Care for Patients With Cognitive Impairment and Primary Care Clinicians: The OPTIMIZE Pragmatic Cluster Randomized Trial. [2022]
13.United Statespubmed.ncbi.nlm.nih.gov
Attitudes toward deprescribing among older adults with dementia in the United States. [2023]
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