Behavioral Task Performance for Psychiatric Symptoms

(CABxtime Trial)

Recruiting at 1 trial location

Overseen By John P O'Doherty, D.Phil

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: California Institute of Technology

Disqualifiers: Neurological disease, Psychotic disorders, Substance use, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

1100 Participants Needed

Trial Summary

What is the purpose of this trial?

This study investigates the computational mechanisms associated with psychiatric disease dimensions. The study will characterize the relationship between computational parameter estimates of task performance and psychiatric symptoms and diagnoses with a longitudinal approach over a 12 month interval. Participants will be healthy participants recruited through Prolific an on-line crowdsourcing service, and psychiatric patients and healthy participants recruited via UCLA Psychiatry Clinics and UCLA's STAND Program

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment Behavioral Task Performance for psychiatric symptoms?

Research shows that problem-solving training can improve coping skills and psychiatric symptoms in patients with schizophrenia, suggesting that similar behavioral task performance treatments might help manage psychiatric symptoms by enhancing problem-solving abilities. ^{1 2 3 4 5}

Is Behavioral Task Performance generally safe for humans?

The research does not provide specific safety data for Behavioral Task Performance in humans, but it discusses the use of cognitive tasks in evaluating drug effects and therapeutic candidates, which can help assess safety profiles. ^{1 6 7 8 9}

How does the Behavioral Task Performance treatment differ from other treatments for psychiatric symptoms?

Behavioral Task Performance is unique because it focuses on improving cognitive functions like motor speed and reaction time, which are linked to psychiatric symptoms such as those in schizophrenia and depression. Unlike traditional treatments that may focus on medication, this approach uses tasks to enhance cognitive mechanisms and address motivational deficits, offering a non-pharmacological option. ^{1 6 10 11 12}

Research Team

John P O'Doherty, D.Phil

Principal Investigator

California Institute of Technology

Eligibility Criteria

This trial is for adults aged 18-65. It includes healthy individuals without psychiatric diagnoses and patients with depression, anxiety disorders, or OCD. Participants must be able to understand and perform tasks and give informed consent. Exclusions are neurological diseases, psychotic disorders, or active substance use disorder.

Inclusion Criteria

Comorbidity with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are allowed

Ability to give informed consent

Ability to give informed consent

Exclusion Criteria

For healthy control participants:

Currently active substance use disorder

I am a patient seeking treatment.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Initial computational assessment task battery to measure individual differences in computational processes

1-2 weeks

1 visit (virtual)

Longitudinal Assessment

Repeated assessments using computational task battery to track changes in computational parameter estimates and psychiatric symptoms

12 months

Multiple visits (virtual)

Follow-up

Participants are monitored for changes in psychiatric symptoms and computational parameter estimates

4 weeks

Treatment Details

Interventions

• Behavioral Task Performance

Trial Overview The study examines how well computational analysis of task performance can predict psychiatric symptoms over a year. It involves both healthy people and those with certain mental health conditions from online platforms and UCLA clinics.

Participant Groups

Group I: Behavioral task battery Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

California Institute of Technology

Lead Sponsor

Trials

17

Recruited

4,300+

References

1. Ireland pubmed.ncbi.nlm.nih.gov

The reliability and validity of the Test of Adaptive Behavior in Schizophrenia (TABS). [2022]

2. United States pubmed.ncbi.nlm.nih.gov

Predictors of change in functional competence and functional behavior after functional adaptation skills training for schizophrenia. [2022]

3. Netherlands pubmed.ncbi.nlm.nih.gov

Generalization effects of training on the Wisconsin Card Sorting Test for schizophrenia patients. [2019]

4. England pubmed.ncbi.nlm.nih.gov

Rapid improvement in beliefs, mood, and performance following an experimental success experience in an analogue test of recovery-oriented cognitive therapy. [2019]

5. Ireland pubmed.ncbi.nlm.nih.gov

Treating problem-solving deficits on an acute care psychiatric inpatient unit. [2019]

6. Netherlands pubmed.ncbi.nlm.nih.gov

Reaction time measures of sustained attention differentiate bipolar disorder from schizophrenia. [2019]

7. United States pubmed.ncbi.nlm.nih.gov

Examining the effects of psychoactive drugs on complex behavioral processes in laboratory animals. [2022]

8. United States pubmed.ncbi.nlm.nih.gov

Evaluating cognitive effort in a randomized controlled trial. [2021]

9. United States pubmed.ncbi.nlm.nih.gov

Assessment of everyday functioning in schizophrenia. [2021]

10. United States pubmed.ncbi.nlm.nih.gov

What determines continuous performance task performance? [2019]

11. Netherlands pubmed.ncbi.nlm.nih.gov

Effort-based decision making as an objective paradigm for the assessment of motivational deficits in schizophrenia. [2015]

12. Ireland pubmed.ncbi.nlm.nih.gov

An ecologically valid performance-based social functioning assessment battery for schizophrenia. [2022]