Post-COVID Syndrome for Chronic Lung Issues
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand why some people continue to feel short of breath and tired after recovering from a severe COVID-19 infection. It will compare individuals who had severe COVID-19 and were hospitalized with those who had mild COVID-19 and fully recovered. Suitable candidates for this trial include those who were hospitalized for severe COVID-19 and now experience ongoing lung issues.
As an unphased trial, this study offers participants the chance to contribute to important research that may enhance understanding and treatment of post-COVID-19 symptoms.
Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to uncover the underlying mechanisms that contribute to chronic lung issues following severe COVID-19 infections. Unlike current treatments that mainly focus on managing symptoms like inflammation and breathing difficulties, this study seeks to identify why some people develop lasting lung problems after COVID-19. Understanding these mechanisms could lead to the development of more targeted and effective therapies in the future, potentially improving long-term outcomes for those affected by severe COVID-19.
Who Is on the Research Team?
Robert Vassallo, MD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Initial Evaluation
Comprehensive clinical evaluation and symptom characterization, quantitative lung CT image analysis and pulmonary function testing, and quality of life questionnaires
Midpoint Evaluation
Continued assessment with clinical evaluations, imaging, and testing, including bronchoscopy with BAL and blood samples
Final Evaluation
Final comprehensive evaluation including bronchoscopy with BAL, blood samples, and quality of life assessments
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
COVID-19 convalescents that recover from prior severe acute diseases requiring hospitalization and who will be at high risk of chronic lung sequelae (with an estimate of \>50% having moderate to severe sequelae based on current literature)
Age and gender matched individuals who had mild SARS-CoV-2 infection and experienced complete resolution of symptoms
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
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