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Behavioural Intervention
Brain-Training Exercises for Long COVID
N/A
Recruiting
Led By Cutter Lindbergh, Ph.D.
Research Sponsored by UConn Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age ≥ 55 years old
TICS ≥ 27
Timeline
Screening 3 weeks
Treatment Varies
Follow Up our feasibility criteria will be assessed by calculating percentages at the conclusion of the study
Awards & highlights
Study Summary
This trial is researching if computerized “brain-training” exercises can help treat Long COVID symptoms in older adults. The results may show that these exercises improve thinking, mood, and daily functioning.
Who is the study for?
This trial is for older adults (55+) who've had COVID-19 and are experiencing ongoing cognitive symptoms that started after their illness. They should be fluent in English, have a certain level of cognitive function (TICS ≥ 27), and not planning to change any psychiatric medication doses during the study. People with neurological disorders, prior cognitive impairments unrelated to COVID-19, significant psychiatric conditions, recent substance use disorders, or major sensory/motor issues can't participate.Check my eligibility
What is being tested?
The trial is testing 'NeuroFlex', which involves computerized brain-training exercises designed as games. The goal is to see if these exercises can help improve thinking, mood, and daily functioning in older adults suffering from Long COVID's lingering effects on cognition.See study design
What are the potential side effects?
Since this intervention involves non-invasive computer tasks, side effects are minimal but may include eye strain or mild frustration due to the nature of brain-training activities.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 55 years old or older.
Select...
My thinking and memory test score is 27 or higher.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ the investigators will evaluate change in total fas score at post-treatment (6 weeks) relative to pre-treatment (baseline)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~the investigators will evaluate change in total fas score at post-treatment (6 weeks) relative to pre-treatment (baseline)
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Credibility/Expectancy Questionnaire (CEQ)
Feasibility (proportion of subjects who agree to participate in the offered treatment, complete assigned exercises, and complete the entire treatment regimen)
System Usability Scale (SUS)
+1 moreSecondary outcome measures
California Verbal Learning Test (CVLT)
Everyday Cognition (ECog)
Fatigue Assessment Scale (FAS)
+5 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Computerized Cognitive RemediationExperimental Treatment1 Intervention
Find a Location
Who is running the clinical trial?
UConn HealthLead Sponsor
211 Previous Clinical Trials
60,581 Total Patients Enrolled
Cutter Lindbergh, Ph.D.Principal InvestigatorUConn Health
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am 55 years old or older.You have had a problem with alcohol or drugs in the past 2 years.I do not have major sensory or motor issues that would stop me from participating in the study.I have ongoing thinking or memory problems after COVID-19 that other conditions don't explain.You had COVID-19 in the past, confirmed by a positive laboratory test or a rapid test.I have ongoing thinking or memory problems after COVID-19 that other conditions don't explain.I do not have any brain conditions that could affect my thinking or participation.I was diagnosed with Mild Cognitive Impairment not related to COVID-19.My thinking and memory test score is 27 or higher.You need to score 27 or more on a test that measures memory and thinking skills.I have been on a stable dose of my psychiatric medication for at least 1 month.You have reported problems with your memory and thinking, with a score of 40 or less on a specific test.You have a history of a serious condition that affects your thinking and learning, like intellectual disability or autism spectrum disorder.
Research Study Groups:
This trial has the following groups:- Group 1: Computerized Cognitive Remediation
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Long COVID Syndrome Patient Testimony for trial: Trial Name: NCT05705193 — N/A
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is enrollment for this clinical experiment still available?
"Unfortunately, according to its listing on clinicaltrials.gov this trial is not soliciting individuals at the present moment. Originally posted on February 8th 2023 and last updated almost a month later, it has ceased recruitment for now; however, there are still 843 other studies requiring participants currently in progress."
Answered by AI
What key aims has this clinical research endeavor set out to achieve?
"This research will use the TAAS Total Score to assess treatment acceptability and adherence at enrolment and post-treatment (6 weeks). Secondary measures are the MADRS, WHODAS and ECog scores. These metrics respectively gauge depressive symptoms, functional disability, and subjective cognitive concern; lower numbers denote improved wellbeing in each category."
Answered by AI
Who else is applying?
What state do they live in?
Alabama
Texas
Vermont
What site did they apply to?
UConn Health
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
1
0
3+
Why did patients apply to this trial?
I'm done with desperate. Have seen several neurologist regarding long-covid but no treatment or plan offered.
PatientReceived 2+ prior treatments
I've had life altering ongoing cognitive symptoms since covid infection 2 years ago.
PatientReceived 1 prior treatment
I believe my autonomic nervous system is damaged and want to try non invasive tools to recover. I have many symptoms of this, not limited to memory.
PatientReceived 2+ prior treatments
I am diagnosed with LC, since January, but have been experiencing symptoms since August. Covid infection was July. I am having cognitive and other issues. Currently disabled, due to this horrible virus. Help!
PatientReceived 2+ prior treatments
What questions have other patients asked about this trial?
can trial be conducted remote?
PatientReceived 1 prior treatment
How responsive is this trial?
Typically responds via
Email
Most responsive sites:
- UConn Health: < 48 hours
Average response time
- < 2 Days
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