Optical Coherence Tomography for Keratoconus
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to improve how doctors identify and treat irregular corneas, which can cause vision issues. Researchers use a technology called OCT (a special scan) to develop better methods for spotting these problems, tracking changes over time, and guiding a treatment called PTK (a laser procedure) for certain corneal conditions. Individuals with conditions like keratoconus (where the cornea bulges), corneal scars, or vision problems after eye surgeries might be suitable candidates. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to advancements in eye care.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
What prior data suggests that these methods are safe for detecting and treating corneal irregularities?
Research has shown that OCT-and-topography guided PTK is generally safe for treating corneal conditions. Studies have found that it often reduces corneal irregularities, improving vision for many. For instance, one study found that this treatment improved vision in about two-thirds of patients by smoothing these irregularities.
Regarding safety, another study confirmed that this method is safe and effective for treating scars on the front part of the cornea. The procedure removes or reduces scar tissue without causing significant harm.
Additionally, research supports using an OCT-based system to assess corneal shape irregularities. OCT provides a detailed map of the cornea, aiding in accurate diagnosis and treatment planning. This system is non-invasive, meaning it doesn't require surgery or cause physical harm to the eye.
Overall, the treatments studied have been shown to be safe and well-tolerated, with few reports of side effects. However, as with any medical procedure, discussing potential risks with a healthcare provider is always advisable.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores innovative ways to diagnose and treat irregular corneas, which can lead to conditions like keratoconus. Unlike traditional methods that rely on less precise imaging, the trial uses state-of-the-art Optical Coherence Tomography (OCT) to get a detailed view of the cornea's shape. This allows for more accurate classification of corneal irregularities and sensitive detection of keratoconus progression. Additionally, the OCT-and-topography guided phototherapeutic keratectomy (PTK) offers a customized approach to treating corneal scars, dystrophy, or high astigmatism, potentially improving vision outcomes more effectively than existing treatments. Overall, these advancements could lead to earlier intervention and better-targeted therapies for patients with irregular corneas.
What evidence suggests that this trial's treatments could be effective for corneal irregularities?
This trial will evaluate different approaches using Optical Coherence Tomography (OCT) for managing irregular corneas. Group C participants will receive OCT-and-topography guided phototherapeutic keratectomy (PTK). Research has shown that this method can correct irregular corneas by addressing corneal scars and high astigmatism, resulting in clearer and more stable vision.
Group A will use OCT as a tool for examining and classifying corneal irregularities. It creates detailed maps of the cornea, aiding doctors in accurately assessing and monitoring conditions like keratoconus. This system enhances the ability to track changes in the cornea over time.
Group B will focus on new OCT measurements developed to detect the progression of keratoconus more effectively. These advanced imaging techniques can identify changes earlier, potentially preventing further vision loss. Overall, OCT-based methods have shown promising results in managing and treating irregular corneas.678910Who Is on the Research Team?
Yan Li, PhD
Principal Investigator
Oregon Health and Science University
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Classification of Corneal Irregularities
Participants' corneal irregularities are classified using OCT and compared against healthy corneas
Detection of Keratoconus Progression
Participants diagnosed with keratoconus are monitored for progression using OCT metrics
OCT-and-Topography Guided PTK
Participants with vision limited by scars, dystrophy, or high astigmatism undergo PTK treatment
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas
- OCT-based system to classify and evaluate corneal-shape irregularities
- OCT metrics for more sensitive detection of keratoconus progression
- Optical Coherence Tomography
Find a Clinic Near You
Who Is Running the Clinical Trial?
Oregon Health and Science University
Lead Sponsor