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Exercise Training for Mild Cognitive Impairment

N/A
Waitlist Available
Led By Ging-Yuek Robin Hsiung, MD, PhD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Have a baseline Montreal Cognitive Assessment (MoCA) score < 26/30
Able to walk independently
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 3 months, 6 months, 12 months, and 18 months
Awards & highlights

Study Summary

This trial will test the effects of AT, RT, and a combination of both on cognitive function in older adults with mild cognitive impairment.

Who is the study for?
This trial is for older adults in Metro Vancouver with mild cognitive impairment, who have a MMSE score of 22 or higher and MoCA score below 26. They should be able to walk, follow the trial's plan, and not be on certain dementia medications. People already doing moderate exercise, diagnosed with dementia other than AD or VCI, at high cardiac risk during exercise, or on cognition-impairing drugs can't join.Check my eligibility
What is being tested?
The study tests how different types of exercises affect brain function in those with mild cognitive impairment. It compares aerobic training (like running), resistance training (like lifting weights), and balance/tone training to see which is best for improving memory and thinking skills.See study design
What are the potential side effects?
Exercise programs generally carry risks like muscle strain or injury from physical activity. Specific side effects will depend on the individual's health condition but are typically low when exercises are done correctly under supervision.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My cognitive test score is below 26 out of 30.
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I can walk on my own without help.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 3 months, 6 months, 12 months, and 18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 3 months, 6 months, 12 months, and 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cognitive function as measured by Alzheimer's Disease Assessment Scale Cognitive Subscale Plus (ADAS-Plus)
Secondary outcome measures
ADAS-Cog Plus
Body composition as measured by DXA
Brain function as measured by functional magnetic resonance imaging (fMRI)
+47 more

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Resistance Training (RT)Experimental Treatment2 Interventions
The RT program will be a four-times-per week program. Twice a week will be resistance training in which a pressurized air system and free weights will be used to provide the training stimulus. Other key strength exercises (with free weights) will include mini-squats, mini-lunges, and lunge walks. The intensity of the training stimulus will initially be at 50% to 60% of 1 repetition maximum (RM) as determined at week two, and progress to 75% to 85% of 1-RM at a work level of 6 to 8 repetitions (2 sets) by week four. The training stimulus will be increased using the 7 RM method, when 2 sets of 6-8 repetitions are completed with proper form. The other two days per week are a balance and tone program consisting of stretching exercises, basic core-strength/kegal exercises, and relaxation techniques. Other than bodyweight, no additional loading (e.g., hand weights, resistance bands, etc.) will be applied to any of the exercises.
Group II: Aerobic Training and Resistance Training (A&RT)Experimental Treatment2 Interventions
The A&RT program will be a four-times-per week program. Twice a week will be aerobic training consisting of outdoor walks with certified fitness instructors. The outdoor walking program will start participants out working at 45% of their heart rate reserve, and work up to 70% of the heart rate reserve. The other two days a week will be resistance training in which a pressurized air system and free weights will be used to provide the training stimulus. Other key strength exercises (with free weights) will include mini-squats, mini-lunges, and lunge walks. The intensity of the training stimulus will initially be at 50% to 60% of 1 repetition maximum (RM) as determined at week two, and progress to 75% to 85% of 1-RM at a work level of 6 to 8 repetitions (2 sets) by week four. The training stimulus will be increased using the 7 RM method, when 2 sets of 6-8 repetitions are completed with proper form.
Group III: Aerobic Training (AT)Experimental Treatment2 Interventions
The AT program will be a four-times-per week program. Twice a week will be aerobic training consisting of outdoor walks with certified fitness instructors. The outdoor walking program will start participants out working at 45% of their heart rate reserve, and work up to 70% of the heart rate reserve. The other two days per week are a balance and tone program consisting of stretching exercises, basic core-strength/kegal exercises, and relaxation techniques. Other than bodyweight, no additional loading (e.g., hand weights, resistance bands, etc.) will be applied to any of the exercises.
Group IV: Balance and Tone Program (CON)Active Control1 Intervention
The CON program will be a four-times-per week program. The CON group will consist of stretching exercises, basic core-strength/kegal exercises, and relaxation techniques. Other than bodyweight, no additional loading (e.g., hand weights, resistance bands, etc.) will be applied to any of the exercises.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic Training
2020
N/A
~830
Resistance Training
2019
Completed Phase 2
~1190
Balance and Tone Training
2017
N/A
~30

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Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,407 Previous Clinical Trials
1,766,333 Total Patients Enrolled
Ging-Yuek Robin Hsiung, MD, PhDPrincipal InvestigatorUniversity of British Columbia
1 Previous Clinical Trials
91 Total Patients Enrolled
Alexander MacKay, PhDPrincipal InvestigatorUniversity of British Columbia

Media Library

Aerobic Training Clinical Trial Eligibility Overview. Trial Name: NCT02737878 — N/A
Mild Cognitive Impairment Research Study Groups: Aerobic Training and Resistance Training (A&RT), Resistance Training (RT), Aerobic Training (AT), Balance and Tone Program (CON)
Mild Cognitive Impairment Clinical Trial 2023: Aerobic Training Highlights & Side Effects. Trial Name: NCT02737878 — N/A
Aerobic Training 2023 Treatment Timeline for Medical Study. Trial Name: NCT02737878 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~21 spots leftby Dec 2024